(Q51387140)

4 April 2018

title

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin. (English)

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4 April 2018

main subject

protein ubiquitination

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8

Ted M Dawson

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4 April 2018

Sathya R Sriram

1

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4 April 2018

Xiaojie Li

2

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4 April 2018

Han Seok Ko

3

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4 April 2018

Kenny K K Chung

4

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4 April 2018

Esther Wong

5

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4 April 2018

Kah Leong Lim

6

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4 April 2018

Valina L Dawson

7

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4 April 2018

publication date

27 July 2005

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4 April 2018

published in

Human Molecular Genetics

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4 April 2018

volume

14

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4 April 2018

page(s)

2571-2586

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4 April 2018

issue

17

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4 April 2018

Parkinson's disease. First of two parts

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Parkinson's disease. Second of two parts

21 January 2018

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Update on Parkinson disease

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A review of xenobiotic metabolism enzymes in Parkinson's disease and motor neuron disease

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Parkinson's disease in twins studied with 18F-dopa and positron emission tomography

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Segregation analysis of Parkinson disease revealing evidence for a major causative gene.

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Epidemiologic study of 203 sibling pairs with Parkinson's disease: the GenePD study.

21 January 2018

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Rare genetic mutations shed light on the pathogenesis of Parkinson disease

21 January 2018

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Genetic clues to the pathogenesis of Parkinson's disease

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Autosomal recessive parkinsonism linked to parkin gene in a Tunisian family. Clinical, genetic and pathological study

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI

21 January 2018

1 reference

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin-deficient mice are not a robust model of parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Loss of locus coeruleus neurons and reduced startle in parkin null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

SEPT5_v2 is a parkin-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin suppresses wild-type alpha-synuclein-induced toxicity in SHSY-5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Association between early-onset Parkinson's disease and mutations in the parkin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Genetics of parkin-linked disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin genetics: one model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Distribution, type, and origin of Parkin mutations: review and case studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin-associated Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Pathogenic mutations inactivate parkin by distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin accumulation in aggresomes due to proteasome impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Complex relationship between Parkin mutations and Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin mutations and susceptibility alleles in late-onset Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

How much phenotypic variation can be attributed to parkin genotype?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin mutations in a patient with hemiparkinsonism-hemiatrophy: a clinical-genetic and PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Parkin disease: a phenotypic study of a large case series

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

New parkin mutations and atypical phenotypes in families with autosomal recessive parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI292

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI292

1 reference

4 April 2018

release_7mb4dbg6w5dhpfkwz45jatytaa

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7mb4dbg6w5dhpfkwz45jatytaa

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

16049031

1 reference

4 April 2018