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BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
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scholarly article
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title
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
(English)
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main subject
regulation of inclusion body assembly
1 reference
stated in
GOA release 2020-03-11
BCL2-associated athanogene 5
1 reference
stated in
GOA release 2020-03-11
dopamine
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based on heuristic
inferred from title
dopaminergic neuron
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based on heuristic
inferred from title
author
Andres Lozano
series ordinal
10
object named as
Andres M Lozano
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Edward A. Fon
series ordinal
8
object named as
Edward A Fon
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author name string
Suneil K Kalia
series ordinal
1
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Sang Lee
series ordinal
2
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Patrice D Smith
series ordinal
3
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Li Liu
series ordinal
4
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Stephen J Crocker
series ordinal
5
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Thorhildur E Thorarinsdottir
series ordinal
6
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John R Glover
series ordinal
7
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David S Park
series ordinal
9
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language of work or name
English
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publication date
16 December 2004
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published in
Neuron
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volume
44
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issue
6
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page(s)
931-45
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cites work
The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin suppresses wild-type alpha-synuclein-induced toxicity in SHSY-5Y cells
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
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7 January 2021
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inferred from DOI database lookup
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
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inferred from DOI database lookup
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
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7 January 2021
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inferred from DOI database lookup
Are ubiquitination pathways central to Parkinson's disease?
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
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7 January 2021
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Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases
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reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
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7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
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inferred from DOI database lookup
Parkinson's disease: mechanisms and models
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alpha-synuclein in Lewy bodies
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular chaperone targeting and regulation by BAG family proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic clues to the pathogenesis of Parkinson's disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting programmed cell death in neurodegenerative diseases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heat-shock proteins as regulators of apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkinson's disease. First of two parts
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Crossref
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https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
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7 January 2021
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inferred from DOI database lookup
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
c-Jun mediates axotomy-induced dopamine neuron death in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of in vivo HSP70 chaperone activity by Hip and Bag-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAG4/SODD protein contains a short BAG domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin accumulation in aggresomes due to proteasome impairment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAG-1 modulates the chaperone activity of Hsp70/Hsc70.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian protein RAP46: an interaction partner and modulator of 70 kDa heat shock proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAG1 over-expression in brain protects against stroke.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Impairment of the ubiquitin-proteasome system by protein aggregation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ubiquitin system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FJ.NEURON.2004.11.026
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/J.NEURON.2004.11.026
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2702027
Fatcat ID
release_tov2pdjanbejrm6xay45w3z2kq
0 references
OpenCitations bibliographic resource ID
2702027
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2702027
PubMed publication ID
15603737
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2702027
ResearchGate publication ID
8125696
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