(Q35844782)

10 August 2017

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title

Genetic clues to the pathogenesis of Parkinson's disease (English)

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10 August 2017

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2

Serge Przedborski

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10 August 2017

Miquel Vila

1

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PubMed ID

15272270

10 August 2017

language of work or name

English

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publication date

1 July 2004

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10 August 2017

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10 August 2017

10 Suppl

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10 August 2017

S58-62

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https://scigraph.springernature.com/pub.10.1038/nm1068

10 August 2017

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cites work

Parkinson's disease: mechanisms and models

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7 January 2021

Staging of brain pathology related to sporadic Parkinson's disease

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7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 January 2021

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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7 January 2021

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

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7 January 2021

Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease

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7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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7 January 2021

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

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7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

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7 January 2021

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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7 January 2021

Yeast cells provide insight into alpha-synuclein biology and pathobiology

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7 January 2021

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

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7 January 2021

Structural determinants of PLD2 inhibition by alpha-synuclein

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7 January 2021

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

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7 January 2021

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

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7 January 2021

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

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7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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7 January 2021

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

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7 January 2021

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

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7 January 2021

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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7 January 2021

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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7 January 2021

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

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7 January 2021

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

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7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

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7 January 2021

UCHL1 is a Parkinson's disease susceptibility gene.

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7 January 2021

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

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7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

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7 January 2021

Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins

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7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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7 January 2021

Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation

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7 January 2021

The role of pathogenic DJ-1 mutations in Parkinson's disease.

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7 January 2021

Pathways to Parkinsonism

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7 January 2021

DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor

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7 January 2021

DJ-1 has a role in antioxidative stress to prevent cell death

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7 January 2021

The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad

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7 January 2021

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

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7 January 2021

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

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7 January 2021

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

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7 January 2021

Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36

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7 January 2021

PARK6-linked parkinsonism occurs in several European families.

1 reference

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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7 January 2021

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

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7 January 2021

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.

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7 January 2021

Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study

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7 January 2021

Lewy bodies and parkinsonism in families with parkin mutations

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7 January 2021

Identifiers

DOI

10.1038/NM1068

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10 August 2017

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PubMed ID

15272270