(Q40174509)

18 September 2017

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid (English)

1 reference

18 September 2017

Ian Paterson

1

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PubMed ID

17279257

18 September 2017

Nicola M Gardner

series ordinal

2

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PubMed ID

17279257

18 September 2017

language of work or name

English

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publication date

23 November 2006

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18 September 2017

Chemical Communications

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18 September 2017

1

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18 September 2017

49-51

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Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta

18 September 2017

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Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

21 January 2018

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Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice

21 January 2018

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Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin

21 January 2018

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Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

21 January 2018

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Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity

21 January 2018

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Natural product hybrids as new leads for drug discovery

21 January 2018

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A practical synthesis of (+)-discodermolide and analogues: fragment union by complex aldol reactions

21 January 2018

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A second-generation total synthesis of (+)-discodermolide: the development of a practical route using solely substrate-based stereocontrol

21 January 2018

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Highly enantioselective borane reduction of ketones catalyzed by chiral oxazaborolidines. Mechanism and synthetic implications

21 January 2018

1 reference

Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.

21 January 2018

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Toward understanding how the lactone moiety of discodermolide affects activity.

21 January 2018

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Synthesis and biological assessment of simplified analogues of the potent microtubule stabilizer (+)-discodermolide

21 January 2018

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Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity

21 January 2018

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Directed reduction of .beta.-hydroxy ketones employing tetramethylammonium triacetoxyborohydride

21 January 2018

1 reference

The Tubulin-Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide

21 January 2018

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Direct synthesis of Z-unsaturated esters. A useful modification of the horner-emmons olefination

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B615122A

1 reference

18 September 2017

1 reference

PubMed ID

17279257