(Q40191918)

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Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.

scientific article published on 10 November 2006

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23 December 2019

Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells (English)

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23 December 2019

Susan P.C. Cole

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23 December 2019

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Shelagh E L Mirski

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23 December 2019

Kathryn E Sparks

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23 December 2019

Beate Friedrich

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23 December 2019

Matthias Köhler

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23 December 2019

Yin-Yuan Mo

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23 December 2019

William T Beck

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23 December 2019

Experimental Cell Research

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23 December 2019

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23 December 2019

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23 December 2019

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23 December 2019

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Sequence determinants of nuclear localization in the alpha and beta isoforms of human topoisomerase II.

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Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases

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Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme

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Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

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Differential sensitivities of recombinant human topoisomerase IIalpha and beta to various classes of topoisomerase II-interacting agents

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Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity.

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Drugs acting on the beta isoform of human topoisomerase II (p180).

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Two COOH-terminal truncated cytoplasmic forms of topoisomerase II alpha in a VP-16-selected lung cancer cell line result from partial gene deletion and alternative splicing

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A truncated cytoplasmic topoisomerase IIalpha in a drug-resistant lung cancer cell line is encoded by a TOP2A allele with a partial deletion of exon 34.

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7 January 2021

Essential mitotic functions of DNA topoisomerase IIalpha are not adopted by topoisomerase IIbeta in human H69 cells

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Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta

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7 January 2021

Human topoisomerase IIalpha nuclear export is mediated by two CRM-1-dependent nuclear export signals

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7 January 2021

Recent developments in DNA topoisomerase II structure and mechanism

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7 January 2021

Structure and mechanism of DNA topoisomerase II

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Cell density-dependent VP-16 sensitivity of leukaemic cells is accompanied by the translocation of topoisomerase IIalpha from the nucleus to the cytoplasm

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7 January 2021

The cytoplasmic trafficking of DNA topoisomerase IIalpha correlates with etoposide resistance in human myeloma cells

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7 January 2021

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

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7 January 2021

Cell fusion studies to examine the mechanism for etoposide resistance in Chinese hamster V79 spheroids

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Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

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Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor

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Regulation of BRCA1, BRCA2 and BARD1 intracellular trafficking

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Regulation of nuclear transport: central role in development and transformation?

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7 January 2021

Overexpression of human DNA topoisomerase II alpha by fusion to enhanced green fluorescent protein.

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Epitope distribution of randomly established monoclonal antibodies against human type II DNA topoisomerases

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Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import

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Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

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Putative reaction intermediates in Crm1-mediated nuclear protein export.

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A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export

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Electroporation in ‘intracellular’ buffer increases cell survival

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Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin.

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Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region

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Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha

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Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors

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Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family

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Three distinct classes of the alpha-subunit of the nuclear pore-targeting complex (importin-alpha) are differentially expressed in adult mouse tissues.

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Importin α: a multipurpose nuclear-transport receptor

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Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors.

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A gamma-2 herpesvirus nucleocytoplasmic shuttle protein interacts with importin alpha 1 and alpha 5.

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The nuclear import of RCC1 requires a specific nuclear localization sequence receptor, karyopherin alpha3/Qip

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Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5

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Nucleocytoplasmic shuttling of signal transducers.

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Physiological regulation of eukaryotic topoisomerase II

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Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity

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Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon

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The topoisomerase II-Hsp90 complex: a new chemotherapeutic target?

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Histone deacetylase 4 possesses intrinsic nuclear import and export signals

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Involvement of 14-3-3 proteins in nuclear localization of telomerase

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Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.

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Unlocking the code of 14-3-3.

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10.1016/J.YEXCR.2006.11.004

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23 December 2019

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23 December 2019

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