(Q40192152)

18 September 2017

title

Assessment of the first and second generation antihistamines brain penetration and role of P-glycoprotein (English)

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18 September 2017

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Tanja Obradovic

1

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18 September 2017

Glenn G Dobson

2

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18 September 2017

Tomotaka Shingaki

3

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18 September 2017

Thomas Kungu

4

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18 September 2017

Ismael J Hidalgo

5

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18 September 2017

publication date

19 December 2006

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18 September 2017

published in

Pharmaceutical Research

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18 September 2017

volume

24

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18 September 2017

issue

2

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18 September 2017

page(s)

318-327

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Advances in H1-antihistamines

18 September 2017

cites work

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https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Factors involved in the absence of sedative effects by the second-generation antihistamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Is there a difference in the affinity of histamine H1 receptor antagonists for CNS and peripheral receptors? An in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

P-glycoprotein limits the brain penetration of nonsedating but not sedating H1-antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

P-Glycoprotein, a gatekeeper in the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Drug efflux transporters in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Multidrug resistance in epilepsy: rats with drug-resistant seizures exhibit enhanced brain expression of P-glycoprotein compared with rats with drug-responsive seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Sedation and antihistamines: a review of inter-drug differences using proportional impairment ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

An evaluation of the effects of high-dose fexofenadine on the central nervous system: a double-blind, placebo-controlled study in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Flavonoid permeability across an in situ model of the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Variations among non-sedating antihistamines: are there real differences?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Prediction of intestinal absorption and blood-brain barrier penetration by computational methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: implications on nose-to-brain transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-9149-4

Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system

21 January 2018

1 reference

12 December 2020

Transport characteristics of diphenhydramine in human intestinal epithelial Caco-2 cells: contribution of pH-dependent transport system.

1 reference

12 December 2020

Comparative study of terfenadine and cetirizine in hay fever: assessment of efficacy and central nervous system effects

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12 December 2020

Permeability of the developing blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique

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12 December 2020

Rational use of in vitro P-glycoprotein assays in drug discovery

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12 December 2020

Diphenhydramine transport by pH-dependent tertiary amine transport system in Caco-2 cells.

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12 December 2020

Tissue levels of several radiolabelled beta-adrenoceptor antagonists after intravenous administration in rats

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12 December 2020

An in situ brain perfusion technique to study cerebrovascular transport in the rat.

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12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

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12 December 2020

10.1007/S11095-006-9149-4

Identifiers

DOI

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18 September 2017

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