(Q40195083)

English

BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth

scientific article published on 14 December 2006

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23 December 2019

BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth (English)

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23 December 2019

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23 December 2019

Paul G. Richardson

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23 December 2019

Kenneth C. Anderson

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23 December 2019

Tanyel Kiziltepe

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23 December 2019

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Hiroshi Ikeda

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23 December 2019

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23 December 2019

Kenji Ishitsuka

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Kenji Ishitsuka

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23 December 2019

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Teru Hideshima

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23 December 2019

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23 December 2019

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Klaus Podar

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23 December 2019

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Janice Jin

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23 December 2019

Yutaka Okawa

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23 December 2019

Sonia Vallet

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23 December 2019

Chris Pargellis

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23 December 2019

Neil Moss

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23 December 2019

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14 December 2006

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23 December 2019

British Journal of Haematology

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23 December 2019

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23 December 2019

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23 December 2019

414-423

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23 December 2019

Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Characterization of HSP27 and three immunologically related polypeptides during Drosophila development.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Hsp27 negatively regulates cell death by interacting with cytochrome c.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

On the role of Hsp27 in regulating apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Transforming growth factor beta receptor I kinase inhibitor down-regulates cytokine secretion and multiple myeloma cell growth in the bone marrow microenvironment

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Advances in biology of multiple myeloma: clinical applications

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

ERK 1,2 and p38 pathways are involved in the proliferative stimuli mediated by urokinase in osteoblastic SaOS-2 cell line

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Modulation of actin dynamics during stress and physiological stimulation by a signaling pathway involving p38 MAP kinase and heat-shock protein 27.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Focus on multiple myeloma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Antimyeloma activity of heat shock protein-90 inhibition.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Friends or foes - bipolar effects of the tumour stroma in cancer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

PRAK, a novel protein kinase regulated by the p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Map kinase signaling pathways and hematologic malignancies

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Mitogen-activated protein kinases in apoptosis regulation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

Heat-shock proteins as death determinants

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2141.2006.06443.X

21 January 2018

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