(Q40203781)

18 September 2017

The codon 72 polymorphism-specific effects of human p53 are absent in mouse cells: implications on generation of mouse models (English)

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18 September 2017

B H Phang

1

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18 September 2017

K Sabapathy

series ordinal

2

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18 September 2017

language of work or name

English

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publication date

20 November 2006

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18 September 2017

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18 September 2017

26

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18 September 2017

21

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18 September 2017

2964-2974

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210112

18 September 2017

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cites work

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

A variation in the structure of the protein-coding region of the human p53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Levels of p53 in Epstein-Barr virus-infected cells determine cell fate: apoptosis, cell cycle arrest at the G1/S boundary without apoptosis, cell cycle arrest at the G2/M boundary without apoptosis, or unrestricted proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Stress-induced p53 runs a transcription-independent death program

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Molecular basis for heterogeneity of the human p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Primary structure polymorphism at amino acid residue 72 of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Tumor suppression and normal aging in mice with constitutively high p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

p53 polymorphic variants at codon 72 exert different effects on cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Regulation of ES cell differentiation by functional and conformational modulation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Transcription, apoptosis and p53: catch-22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Evidence for selective expression of the p53 codon 72 polymorphs: implications in cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Trp53-dependent DNA-repair is affected by the codon 72 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

p53 polymorphisms and haplotypes in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Two polymorphic variants of wild-type p53 differ biochemically and biologically

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Relief of p53-mediated telomerase suppression by p73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Evaluation of the combined effect of p53 codon 72 polymorphism and hotspot mutations in response to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

The transcriptional targets of p53 in apoptosis control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

Is p53 polymorphism maintained by natural selection?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

Tumor Susceptibility and Apoptosis Defect in a Mouse Strain Expressing a Human p53 Transgene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

Phosphorylation of murine p53, but not human p53, by MAP kinase in vitro and in cultured cells highlights species-dependent variation in post-translational modification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

Ectopic mTERT expression in mouse embryonic stem cells does not affect differentiation but confers resistance to differentiation- and stress-induced p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

p53 codon 72 polymorphism as a risk factor in the development of breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210112

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210112

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Dimensions Publication ID

18 September 2017

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1 reference