(Q43854589)

27 November 2017

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells (English)

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27 November 2017

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4

Carol Prives

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27 November 2017

Nicole Baptiste

1

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27 November 2017

Philip Friedlander

series ordinal

2

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27 November 2017

Xinbin Chen

series ordinal

3

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27 November 2017

language of work or name

English

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publication date

1 January 2002

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27 November 2017

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27 November 2017

21

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27 November 2017

9-21

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27 November 2017

1

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205015

27 November 2017

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cites work

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The role of p53 in tumour suppression: lessons from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Recruitment of p300/CBP in p53-dependent signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Growth factor modulation of p53-mediated growth arrest versus apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The cell cycle effects of camptothecin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Regulation of p53 downstream genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53 and chemosensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Sensitization of tumors to chemotherapy through gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Synergistic activation of transcription by CBP and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Covalent and noncovalent modifiers of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A p53-independent damage-sensing mechanism that functions as a checkpoint at the G1/S transition in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Proteolytic cleavage of p53 mutants in response to mismatched DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Mechanisms of switching on p53: a role for covalent modification?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A novel form of Epstein-Barr virus latency in normal B cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A role of cyclin G in the process of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Redox state regulates binding of p53 to sequence-specific DNA, but not to non-specific or mismatched DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Clinical implications of p53: effect on prognosis, tumor progression and chemotherapy response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A model for p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Regulation and function of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Mechanism of action of antitumor drug etoposide: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Clinical implications of p53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Predicting response to cancer chemotherapy: the role of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p21 is a universal inhibitor of cyclin kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Role of BAX in the apoptotic response to anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Identification of a novel p53 functional domain that is necessary for mediating apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Definition of the p53 functional domains necessary for inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

Modulation of p53 function in cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Topoisomerase-targeting antitumor drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

General features of the recognition by tubulin of colchicine and related compounds

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

p53 in growth control and neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

5-fluorouracil: a pharmacological paradigm in the use of cytotoxics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Cell-cycle arrest versus cell death in cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205015

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205015

1 reference

Dimensions Publication ID

27 November 2017

0 references

1 reference