(Q40209862)

English

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells.

scientific article published on 15 December 2011

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170099%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170099%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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multiple drug resistance

1 reference

based on heuristic

inferred from title

Martin Michaelis

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22170099%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Rainer Breitling

8

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18 January 2020

12

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18 January 2020

Andreas von Deimling

9

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18 January 2020

Thorsten Stiewe

14

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18 January 2020

author name string

F Rothweiler

2

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18 January 2020

S Barth

3

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18 January 2020

J Cinatl

4

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18 January 2020

M van Rikxoort

5

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18 January 2020

N Löschmann

6

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18 January 2020

Y Voges

7

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18 January 2020

F Rödel

10

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18 January 2020

K Weber

11

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18 January 2020

E Mack

13

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18 January 2020

H W Doerr

15

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18 January 2020

D Speidel

16

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Europe PubMed Central

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18 January 2020

J Cinatl

17

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Europe PubMed Central

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18 January 2020

publication date

15 December 2011

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18 January 2020

Cell Death and Disease

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18 January 2020

2

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18 January 2020

e243

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18 January 2020

describes a project that uses

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COLO-679rNutlin20muM

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COLO-679rPLX4032_10muM

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MelHOrNutlin20muM

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MelHOrPLX4032_10muM

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UKF-NB-2rCDDP1000

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UKF-NB-3rCDDP1000

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UKF-NB-3rDACARB8

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UKF-NB-3rGEMCI10

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UKF-NB-3rIRINO800

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UKF-NB-3rMEL400

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UKF-NB-3rNutlin10muM

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UKF-NB-3rOXALI2000

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UKF-NB-3rTOPO15

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UKF-NB-3rVINOR20

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UKF-NB-6rNutlin10muM

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UKF-Rhb-1rCDDP1000

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UKF-Rhb-1rDOCE10

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UKF-Rhb-1rDOX10

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UKF-Rhb-1rGEMCI10

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UKF-Rhb-1rIRINO200

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UKF-Rhb-1rMEL400

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UKF-Rhb-1rOXALI1000

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UKF-Rhb-1rVCR10

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1 reference

Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/3252738

based on heuristic

inferred from PubMed Central ID database lookup

Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

22 September 2017

Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

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22 September 2017

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

22 September 2017

Anticancer effects of the nitric oxide-modified saquinavir derivative saquinavir-NO against multidrug-resistant cancer cells

1 reference

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22 September 2017

Reactivation of p53: from peptides to small molecules.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

22 September 2017

Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

22 September 2017

High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma

1 reference

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22 September 2017

Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

1 reference

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22 September 2017

MI-63: a novel small-molecule inhibitor targets MDM2 and induces apoptosis in embryonal and alveolar rhabdomyosarcoma cells with wild-type p53.

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22 September 2017

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22 September 2017

When mutants gain new powers: news from the mutant p53 field.

1 reference

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22 September 2017

Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells

1 reference

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22 September 2017

Reversal of P-glycoprotein-mediated multidrug resistance by the murine double minute 2 antagonist nutlin-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

22 September 2017

Transient nutlin-3a treatment promotes endoreduplication and the generation of therapy-resistant tetraploid cells

1 reference

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22 September 2017

The role of p53 in pigmentation, tanning and melanoma

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Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties

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22 September 2017

The oncogenic roles of p53 mutants in mouse models

1 reference

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22 September 2017

Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252738

22 September 2017

PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways

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22 September 2017

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1 reference

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22 September 2017

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

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22 September 2017

Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse

1 reference

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22 September 2017

Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.

1 reference

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22 September 2017

The p53 pathway and its inactivation in neuroblastoma.

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Loss of p53 function confers high-level multidrug resistance in neuroblastoma cell lines

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DNA damage response to the Mdm2 inhibitor nutlin-3.

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/CDDIS.2011.129

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Europe PubMed Central

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18 January 2020

PMC publication ID

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Europe PubMed Central

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18 January 2020

PubMed publication ID

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Europe PubMed Central

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18 January 2020

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