(Q40216264)

18 September 2017

Down syndrome candidate region 1 increases the stability of the IkappaBalpha protein: implications for its anti-inflammatory effects (English)

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18 September 2017

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Young Sun Kim

1

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18 September 2017

Kyung-Ok Cho

2

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18 September 2017

Hong Joon Lee

3

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18 September 2017

Seong Yun Kim

4

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18 September 2017

Yasufumi Sato

5

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18 September 2017

Young-Jin Cho

6

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18 September 2017

language of work or name

English

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publication date

24 October 2006

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Journal of Biological Chemistry

18 September 2017

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18 September 2017

281

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18 September 2017

39051-39061

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18 September 2017

51

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A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart

18 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

The role of modulatory calcineurin-interacting proteins in calcineurin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

VEGF selectively induces Down syndrome critical region 1 gene expression in endothelial cells: a mechanism for feedback regulation of angiogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Coculture of THP-1 human mononuclear cells with Candida albicans results in pronounced changes in host gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Depolarization of neural cells induces transcription of the Down syndrome critical region 1 isoform 4 via a calcineurin/nuclear factor of activated T cells-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Raf-1 is a binding partner of DSCR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Induction of COX-2 and PGE(2) biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Activation of IkappaB kinase beta by protein kinase C isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Down syndrome candidate region 1,a downstream target of VEGF, participates in endothelial cell migration and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Signal-dependent and -independent degradation of free and NF-kappa B-bound IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Cytokines role in neurodegenerative events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

NF-kappaB in neuronal plasticity and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Global cerebral ischemia activates nuclear factor-kappa B prior to evidence of DNA fragmentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

NF-kappaB is activated and promotes cell death in focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

Neuronal activation of NF-kappaB contributes to cell death in cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604659200

21 January 2018

Identifiers

DOI

10.1074/JBC.M604659200

1 reference

18 September 2017

1 reference