(Q40219887)

English

A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo

scientific article published on 16 October 2006

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scholarly article

1 reference

Europe PubMed Central

18 September 2017

A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo (English)

1 reference

Europe PubMed Central

18 September 2017

Antonio Giordano

9

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Europe PubMed Central

18 September 2017

author name string

Bagella L

1

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Europe PubMed Central

18 September 2017

Sun A

2

1 reference

Europe PubMed Central

18 September 2017

Tonini T

3

1 reference

Europe PubMed Central

18 September 2017

Abbadessa G

4

1 reference

Europe PubMed Central

18 September 2017

Cottone G

5

1 reference

Europe PubMed Central

18 September 2017

Paggi MG

6

1 reference

Europe PubMed Central

18 September 2017

De Luca A

7

1 reference

Europe PubMed Central

18 September 2017

Claudio PP

8

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Europe PubMed Central

18 September 2017

language of work or name

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publication date

16 October 2006

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Europe PubMed Central

18 September 2017

1 reference

Europe PubMed Central

18 September 2017

26

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Europe PubMed Central

18 September 2017

1829-1839

1 reference

Europe PubMed Central

18 September 2017

13

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Europe PubMed Central

18 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209987

0 references

Overexpression of G1-S cyclins and cyclin-dependent kinases during multistage human pancreatic duct cell carcinogenesis

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The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity

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Identification of murine cdk10: association with Ets2 transcription factor and effects on the cell cycle

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Cdk2 knockout mice are viable

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Role of cell-cycle regulators in lung cancer

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Cdk2-dependent phosphorylation of the NF-Y transcription factor is essential for the expression of the cell cycle-regulatory genes and cell cycle G1/S and G2/M transitions

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Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

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Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancer.

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Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents

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Retinoblastoma family genes

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CDK inhibitors in clinical development for the treatment of cancer

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Are RB proteins a potential substrate of Pin1 in the regulation of the cell cycle?

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Cyclin E ablation in the mouse

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Cell cycle control and beyond: emerging roles for the retinoblastoma gene family

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Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.

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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

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Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells.

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Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells

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A cell cycle regulator potentially involved in genesis of many tumor types

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

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Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors.

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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

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Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes

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Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer

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Mammalian cyclin-dependent kinases

1 reference

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

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A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry

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Cyclin-dependent kinases: engines, clocks, and microprocessors

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

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Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia

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Interaction of PP2A catalytic subunit with Rb2/p130 is required for all-trans retinoic acid suppression of ovarian carcinoma cell growth

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21 January 2018

Different roles for cyclins D1 and E in regulation of the G1-to-S transition

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Small-molecule cyclin-dependent kinase modulators

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Cyclin-dependent kinase pathways as targets for cancer treatment

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Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine

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Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: induction of cyclin A and enhanced CDK2 activity

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Proliferation of cancer cells despite CDK2 inhibition.

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Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach

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The retinoblastoma protein and cell cycle control

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p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

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Anti-proliferation effect of 3-amino-2-imino-3,4-dihydro-2H-1,3-benzothiazin-4-one (BJ-601) on human vascular endothelial cells: G0/G1 p21-associated cell cycle arrest

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p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.

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Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes

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based on heuristic

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A Unique Domain of pRb2/p130 Acts as an Inhibitor of Cdk2 Kinase Activity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmaceutical research in molecular oncology

1 reference

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inferred from DOI database lookup

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

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Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett's esophagus

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A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

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10.1038/SJ.ONC.1209987

1 reference

Europe PubMed Central

18 September 2017

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https://api.fatcat.wiki/v0/release/p7lb5bs5hbc6rcwqlds7g4s6ny

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

18 September 2017

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