(Q40230307)

18 September 2017

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway (English)

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18 September 2017

9

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18 September 2017

C Bonner

5

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author name string

C G Concannon

1

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18 September 2017

B F Koehler

2

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18 September 2017

Claus Reimertz

3

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18 September 2017

B M Murphy

4

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18 September 2017

N Thurow

6

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18 September 2017

M W Ward

7

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18 September 2017

A Villunger

8

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18 September 2017

D Kögel

10

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18 September 2017

J H M Prehn

11

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18 September 2017

language of work or name

English

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publication date

18 September 2006

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18 September 2017

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18 September 2017

26

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18 September 2017

1681-1692

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18 September 2017

12

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209974

18 September 2017

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cites work

Proteasome inhibitors as new anticancer drugs

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The proteasome: a suitable antineoplastic target

21 January 2018

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Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma

21 January 2018

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Proteasome inhibition induces hepatic stellate cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

21 January 2018

1 reference

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Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibition in multiple myeloma: therapeutic implication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

21 January 2018

1 reference

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

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Epoxomicin, a new antitumor agent of microbial origin

21 January 2018

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NF-kappa B as a therapeutic target in multiple myeloma

21 January 2018

1 reference

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Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

21 January 2018

1 reference

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IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

21 January 2018

1 reference

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Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Phase I trial of the proteasome inhibitor bortezomib in patients with advanced solid tumors with observations in androgen-independent prostate cancer

21 January 2018

1 reference

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The role of proteasome inhibitors in solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Ca(2+)-induced inhibition of apoptosis in human SH-SY5Y neuroblastoma cells: degradation of apoptotic protease activating factor-1 (APAF-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

A phase 2 study of bortezomib in relapsed, refractory myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Apoptosis induction resulting from proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Life in the balance: how BH3-only proteins induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209974

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1209974

1 reference

Dimensions Publication ID

18 September 2017

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1 reference