(Q40251788)

English

Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines.

scientific article published on February 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

0 references

1 reference

based on heuristic

inferred from title

Yusuke Furukawa

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

author name string

Yasuhiko Kano

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Miyuki Akutsu

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Saburo Tsunoda

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Tohru Izumi

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Hiroyuki Kobayashi

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Hiroyuki Mano

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

publication date

1 February 2007

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Investigational New Drugs

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

25

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

31-40

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16865529%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

https://scigraph.springernature.com/pub.10.1007/s10637-006-9000-0

0 references

Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells

1 reference

https://api.crossref.org/works/10.1007%2FS10637-006-9000-0

21 January 2018

The histone deacetylase inhibitor FR901228 (desipeptide) restores expression and function of pseudo-null p53.

1 reference

https://api.crossref.org/works/10.1007%2FS10637-006-9000-0

21 January 2018

Depsipeptide (FR901228): a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase: a regulator of transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone acetylases and deacetylases in cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase as a therapeutic target

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of ARG kinase activity by STI571 induces cell cycle arrest through up-regulation of CDK inhibitor p18/INK4c.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiproliferative effects of the histone deacetylase inhibitor FR901228 on small-cell lung cancer lines and drug-resistant sublines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What is synergy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FR901228, an inhibitor of histone deacetylases, increases the cellular responsiveness to IL-6 type cytokines by enhancing the expression of receptor proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitor FK228 suppresses the Ras-MAP kinase signaling pathway by upregulating Rap1 and induces apoptosis in malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of amsacrine in combination with other anticancer agents in human acute lymphoblastic leukemia cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro schedule-dependent interaction between paclitaxel and SN-38 (the active metabolite of irinotecan) in human carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16865529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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