(Q46902523)

English

Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib.

scientific article published in January 2006

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scholarly article

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15 January 2020

Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424655%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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Yusuke Furukawa

7

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15 January 2020

author name string

Krittaya Sutheesophon

1

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15 January 2020

Yukiko Kobayashi

2

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15 January 2020

Masa-aki Takatoku

3

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15 January 2020

Keiya Ozawa

4

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15 January 2020

Yasuhiko Kano

5

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15 January 2020

Hideshi Ishii

6

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15 January 2020

publication date

1 January 2006

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15 January 2020

Acta Haematologica

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15 January 2020

115

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15 January 2020

1-2

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15 January 2020

78-90

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15 January 2020

Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Regulation of E2F1 activity by acetylation

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Histone deacetylases as therapeutic targets in hematologic malignancies

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The ubiquitin system

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Roles of ubiquitin-mediated proteolysis in cell cycle control

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The development of proteasome inhibitors as anticancer drugs

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Apaf-1 is a mediator of E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Cytochrome C-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Phase I study of bortezomib in refractory or relapsed acute leukemias

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Bax, along with lipid conspirators, allows cytochrome c to escape mitochondria

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Expression of Bcl-2 family of proteins in fresh myeloma cells.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Impact of the expression of P glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat shock protein 27 on response to induction therapy and long-term survival in patients with de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Identifiers

10.1159/000089471

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424655%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424655%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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