(Q46902523)

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Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib.

scientific article published in January 2006

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15 January 2020

Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424655%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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Yusuke Furukawa

7

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15 January 2020

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Krittaya Sutheesophon

1

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15 January 2020

Yukiko Kobayashi

2

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15 January 2020

Masa-aki Takatoku

3

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15 January 2020

Keiya Ozawa

4

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15 January 2020

Yasuhiko Kano

5

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15 January 2020

Hideshi Ishii

6

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15 January 2020

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1 January 2006

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15 January 2020

Acta Haematologica

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15 January 2020

115

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15 January 2020

1-2

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15 January 2020

78-90

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15 January 2020

Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Regulation of E2F1 activity by acetylation

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Histone deacetylases as therapeutic targets in hematologic malignancies

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The ubiquitin system

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Roles of ubiquitin-mediated proteolysis in cell cycle control

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The development of proteasome inhibitors as anticancer drugs

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Apaf-1 is a mediator of E2F-1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Cytochrome C-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Phase I study of bortezomib in refractory or relapsed acute leukemias

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Bax, along with lipid conspirators, allows cytochrome c to escape mitochondria

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Combined p53/Bax mutation results in extremely poor prognosis in gastric carcinoma with low microsatellite instability

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Expression of Bcl-2 family of proteins in fresh myeloma cells.

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Impact of the expression of P glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat shock protein 27 on response to induction therapy and long-term survival in patients with de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1159%2F000089471

21 January 2018

Identifiers

10.1159/000089471

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424655%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16424655%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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