(Q40270975)

19 September 2017

title

Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve (English)

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19 September 2017

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Thomas Vormberge

1

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19 September 2017

Michael Hoffmann

series ordinal

2

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19 September 2017

Herbert Himmel

series ordinal

3

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19 September 2017

publication date

25 April 2006

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Journal of Pharmacological and Toxicological Methods

19 September 2017

published in

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19 September 2017

volume

54

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19 September 2017

issue

2

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19 September 2017

page(s)

130-140

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The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Assessing predictors of drug-induced torsade de pointes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Interaction of different potassium channels in cardiac repolarization in dog ventricular preparations: role of repolarization reserve

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Do existing measures of Poincaré plot geometry reflect nonlinear features of heart rate variability?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

The impact of drug-induced QT interval prolongation on drug discovery and development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Comparability of the electrophysiologic responses and plasma and myocardial tissue concentrations of sotalol and its d stereoisomer in the dog

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Clinical pharmacokinetics of sotalol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Probing the interaction between inactivation gating and Dd-sotalol block of HERG.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Pharmacokinetics of the -adrenergic blocker sotalol in dogs.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Action potential prolongation exhibits simple dose-dependence for sotalol, but reverse dose-dependence for quinidine and disopyramide: implications for proarrhythmia due to triggered activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.VASCN.2006.03.011

10.1016/J.VASCN.2006.03.011

7 January 2021

Identifiers

DOI

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19 September 2017

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