(Q40282285)

English

Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells

scientific article published on 8 May 2006

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scholarly article

1 reference

Europe PubMed Central

19 September 2017

Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells (English)

1 reference

Europe PubMed Central

19 September 2017

breast carcinoma

1 reference

based on heuristic

inferred from title

author name string

Manuvakhova M

1

1 reference

Europe PubMed Central

19 September 2017

Thottassery JV

2

1 reference

Europe PubMed Central

19 September 2017

Hays S

3

1 reference

Europe PubMed Central

19 September 2017

Qu Z

4

1 reference

Europe PubMed Central

19 September 2017

Rentz SS

5

1 reference

Europe PubMed Central

19 September 2017

Westbrook L

6

1 reference

Europe PubMed Central

19 September 2017

Kern FG

7

1 reference

Europe PubMed Central

19 September 2017

language of work or name

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publication date

8 May 2006

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Europe PubMed Central

19 September 2017

1 reference

Europe PubMed Central

19 September 2017

25

1 reference

Europe PubMed Central

19 September 2017

44

1 reference

Europe PubMed Central

19 September 2017

6003-6014

1 reference

Europe PubMed Central

19 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209592

0 references

Insulators and boundaries: versatile regulatory elements in the eukaryotic genome

1 reference

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Signaling through Ras is essential for ret oncogene-induced cell differentiation in PC12 cells.

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Structural and functional analysis of pp70S6k

1 reference

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Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

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Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

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Use of G-protein fusions to monitor integral membrane protein-protein interactions in yeast.

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

1 reference

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

1 reference

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Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

1 reference

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Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

1 reference

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Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

1 reference

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

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c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells.

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Amplification of fgfr4 gene in human breast and gynecological cancers

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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Neurite growth promotion by nerve growth factor and insulin-like growth factor-1 in cultured adult sensory neurons: role of phosphoinositide 3-kinase and mitogen activated protein kinase.

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Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

1 reference

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Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation

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A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

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Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins

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Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

1 reference

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The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway

1 reference

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21 January 2018

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

1 reference

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Rheb fills a GAP between TSC and TOR.

1 reference

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Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis

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The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

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Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

1 reference

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21 January 2018

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

1 reference

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21 January 2018

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

1 reference

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Homogeneity and long-term stability of tetracycline-regulated gene expression with low basal activity by using the rtTA2S-M2 transactivator and insulator-flanked reporter vectors

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SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells

1 reference

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Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

1 reference

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p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex

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Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

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Cell- and receptor isotype-specific phosphorylation of SNT1 by fibroblast growth factor receptor tyrosine kinases

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EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

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Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells

1 reference

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Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

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Raptor, a binding partner of target of rapamycin

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Early BDNF, NT-3, and NT-4 signaling events

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MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice

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Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.

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Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2.

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Mechanism of activation of protein kinase B by insulin and IGF-1

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Expression of FGF and FGF receptor genes in human breast cancer

1 reference

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Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling

1 reference

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TrkC isoforms with inserts in the kinase domain show impaired signaling responses

1 reference

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7 January 2021

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Nutritional support of brain-injured patients. Brain Trauma Foundation

1 reference

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DNR, but business as usual

1 reference

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The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer

1 reference

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Identifiers

10.1038/SJ.ONC.1209592

1 reference

Europe PubMed Central

19 September 2017

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1 reference

Europe PubMed Central

19 September 2017

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