(Q40293917)

English

The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal

scientific article published on 11 April 2006

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal (English)

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

single-nucleotide polymorphism

1 reference

based on heuristic

inferred from title

author name string

Yasunari Sakai

1

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Hisanobu Oda

2

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Daisuke Yoshimura

3

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Masato Furuichi

4

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Dongchon Kang

5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Shigenori Iwai

6

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Toshiro Hara

7

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Yusaku Nakabeppu

8

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

publication date

11 April 2006

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

Journal of Molecular Medicine

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

84

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

660-670

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

https://scigraph.springernature.com/pub.10.1007/s00109-006-0053-5

0 references

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0053-5

21 January 2018

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0053-5

21 January 2018

Molecular genetics and structural biology of human MutT homolog, MTH1.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0053-5

21 January 2018

Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0053-5

21 January 2018

Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

1 reference

https://api.crossref.org/works/10.1007%2FS00109-006-0053-5

21 January 2018

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidants, antioxidants, and the degenerative diseases of aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of 8-oxo-2'-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfer of the E. coli O6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computational method to predict mitochondrially imported proteins and their targeting sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MutT-related error avoidance mechanism for DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some unusual nucleic acid bases are products of hydroxyl radical oxidation of DNA and RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A variant form of hMTH1, a human homologue of the E coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of hMTH1 in the hippocampi of control and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/16607562

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00109-006-0053-5

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

release_w2zmssdzs5egndjafrti5clgaa

1 reference

https://api.fatcat.wiki/v0/release/w2zmssdzs5egndjafrti5clgaa

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

19 September 2017

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