(Q40325493)

19 September 2017

title

Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation (English)

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19 September 2017

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Fresnida J Ramos

1

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19 September 2017

Paul R Langlais

2

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19 September 2017

Derong Hu

3

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19 September 2017

Lily Q Dong

4

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19 September 2017

Feng Liu

5

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19 September 2017

publication date

24 January 2006

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American Journal of Physiology - Endocrinology and Metabolism

19 September 2017

published in

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19 September 2017

volume

290

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19 September 2017

issue

6

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19 September 2017

page(s)

E1262-6

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The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor

19 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Grb10 and Grb14: enigmatic regulators of insulin action--and more?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Control of insulin receptor level in 3T3 cells: effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Grb10: more than a simple adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Meg1/Grb10 overexpression causes postnatal growth retardation and insulin resistance via negative modulation of the IGF1R and IR cascades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00609.2005

10.1152/AJPENDO.00609.2005

21 January 2018

Identifiers

DOI

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19 September 2017

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