(Q38359478)

English

Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor

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scholarly article

1 reference

Europe PubMed Central

2 September 2017

Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor (English)

1 reference

Europe PubMed Central

2 September 2017

1 reference

based on heuristic

inferred from title

author name string

KeriLyn R Wick

1

1 reference

Europe PubMed Central

2 September 2017

Eric D Werner

2

1 reference

Europe PubMed Central

2 September 2017

Paul Langlais

3

1 reference

Europe PubMed Central

2 September 2017

Fresnida J Ramos

4

1 reference

Europe PubMed Central

2 September 2017

Lily Q Dong

5

1 reference

Europe PubMed Central

2 September 2017

Steven E Shoelson

6

1 reference

Europe PubMed Central

2 September 2017

Feng Liu

7

1 reference

Europe PubMed Central

2 September 2017

language of work or name

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publication date

18 December 2002

1 reference

Europe PubMed Central

2 September 2017

number of pages

8

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Journal of Biological Chemistry

1 reference

Europe PubMed Central

2 September 2017

278

1 reference

Europe PubMed Central

2 September 2017

10

1 reference

Europe PubMed Central

2 September 2017

8460-8467

1 reference

Europe PubMed Central

2 September 2017

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Role for the adaptor protein Grb10 in the activation of Akt

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

The IRS-signalling system: a network of docking proteins that mediate insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

A simplified system for generating recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M208518200

21 January 2018

Identifiers

10.1074/JBC.M208518200

1 reference

Europe PubMed Central

2 September 2017

1 reference

Europe PubMed Central

2 September 2017

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