(Q40336636)

19 September 2017

title

Mechanistic link between the anti-HCV effect of interferon gamma and control of viral replication by a Ras-MAPK signaling cascade (English)

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19 September 2017

Ying Huang

1

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19 September 2017

Xinyi Cynthia Chen

2

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19 September 2017

Madhavi Konduri

3

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19 September 2017

Nadejda Fomina

4

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19 September 2017

Jin Lu

5

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19 September 2017

Ling Jin

6

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19 September 2017

Alexander Kolykhalov

7

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19 September 2017

Seng-Lai Tan

8

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19 September 2017

language of work or name

English

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publication date

1 January 2006

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19 September 2017

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19 September 2017

volume

43

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19 September 2017

issue

1

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19 September 2017

page(s)

81-90

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Replicon cell culture system as a valuable tool in antiviral drug discovery against hepatitis C virus

19 September 2017

cites work

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Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures

21 January 2018

1 reference

RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.

21 January 2018

1 reference

Activation of protein kinase C delta by IFN-gamma

21 January 2018

1 reference

Hepatitis C infection: a clinical review

21 January 2018

1 reference

7 January 2021

Scope of worldwide hepatitis C problem

1 reference

7 January 2021

Strategies for hepatitis C therapeutic intervention: now and next

1 reference

7 January 2021

Unravelling hepatitis C virus replication from genome to function

1 reference

7 January 2021

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

1 reference

7 January 2021

Efficient initiation of HCV RNA replication in cell culture

1 reference

7 January 2021

Effect of alpha interferon on the hepatitis C virus replicon

1 reference

7 January 2021

Efficient replication of a full-length hepatitis C virus genome, strain O, in cell culture, and development of a luciferase reporter system.

1 reference

7 January 2021

Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.

1 reference

7 January 2021

Interferon-gamma inhibits replication of subgenomic and genomic hepatitis C virus RNAs

1 reference

7 January 2021

Comparative Analysis of Anti-Hepatitis C Virus Activity and Gene Expression Mediated by Alpha, Beta, and Gamma Interferons

1 reference

7 January 2021

Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system

1 reference

7 January 2021

Cytopathic and Noncytopathic Interferon Responses in Cells Expressing Hepatitis C Virus Subgenomic Replicons

1 reference

7 January 2021

Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation

1 reference

7 January 2021

STAT3 induces anti-hepatitis C viral activity in liver cells

1 reference

7 January 2021

Involvement of p38 signaling pathway in interferon-alpha-mediated antiviral activity toward hepatitis C virus

1 reference

7 January 2021

Alpha interferon induces distinct translational control programs to suppress hepatitis C virus RNA replication

1 reference

7 January 2021

New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1

1 reference

7 January 2021

MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products

1 reference

7 January 2021

Specific inhibition of hepatitis C virus replication by cyclosporin A.

1 reference

7 January 2021

Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha

1 reference

7 January 2021

Effect of p38 Mitogen-Activated Protein Kinase on the Replication of Encephalomyocarditis Virus

1 reference

7 January 2021

Hepatitis C virus NS5A: tales of a promiscuous protein

1 reference

7 January 2021

High-throughput screening of the yeast kinome: identification of human serine/threonine protein kinases that phosphorylate the hepatitis C virus NS5A protein

1 reference

7 January 2021

Replication of the hepatitis C virus in cell culture

1 reference

7 January 2021

Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture

1 reference

7 January 2021

Determinants of viral clearance and persistence during acute hepatitis C virus infection

1 reference

7 January 2021

Nonlinear partial differential equations and applications: Genomic analysis of the host response to hepatitis C virus infection

1 reference

7 January 2021

Cell-mediated immunity and the outcome of hepatitis C virus infection

1 reference

7 January 2021

JNK2 and IKKbeta are required for activating the innate response to viral infection

1 reference

7 January 2021

Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression

1 reference

7 January 2021

Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin

1 reference

7 January 2021

Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells

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7 January 2021

Activation of the p38 mitogen-activated protein kinase by type I interferons

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7 January 2021

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons

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7 January 2021

Mechanisms of type-I- and type-II-interferon-mediated signalling

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7 January 2021

The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling

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7 January 2021

Perturbation of epidermal growth factor receptor complex formation and Ras signalling in cells harbouring the hepatitis C virus subgenomic replicon

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7 January 2021

Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway

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7 January 2021

Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway

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7 January 2021

Suppression of the ERK1/2 signaling pathway from HCV NS5A protein expressed by herpes simplex recombinant viruses

1 reference

7 January 2021

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

1 reference

7 January 2021

The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity

1 reference

7 January 2021

How hepatitis C virus counteracts the interferon response: the jury is still out on NS5A.

1 reference

7 January 2021

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

1 reference

7 January 2021

Mutational analysis of hepatitis C virus nonstructural protein 5A: potential role of differential phosphorylation in RNA replication and identification of a genetically flexible domain.

1 reference

7 January 2021

Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit

1 reference

7 January 2021

Hepatitis C virus NS5A protein is phosphorylated by casein kinase II.

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7 January 2021

Ser(2194) is a highly conserved major phosphorylation site of the hepatitis C virus nonstructural protein NS5A.

1 reference

7 January 2021

Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321

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7 January 2021

Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.

1 reference

7 January 2021

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

1 reference

7 January 2021

Interferon-beta-induced activation of c-Jun NH2-terminal kinase mediates apoptosis through up-regulation of CD95 in CH31 B lymphoma cells.

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7 January 2021

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner

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7 January 2021

Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent

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7 January 2021

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

7 January 2021

Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

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7 January 2021

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

1 reference

7 January 2021

Regulation of mRNA Translation and Cellular Signaling by Hepatitis C Virus Nonstructural Protein NS5A

1 reference

7 January 2021

1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2.

1 reference

7 January 2021

Identifiers

DOI

10.1002/HEP.21011

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19 September 2017

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