(Q40343556)

19 September 2017

title

Identification of regulatory sites in the human PXR (NR1I2) promoter region (English)

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19 September 2017

Kouichi Kurose

1

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19 September 2017

Shinobu Ikeda

2

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19 September 2017

Satoru Koyano

3

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19 September 2017

Masahiro Tohkin

4

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19 September 2017

Ryuichi Hasegawa

5

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19 September 2017

Jun-ichi Sawada

6

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19 September 2017

publication date

1 January 2006

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Molecular and Cellular Biochemistry

19 September 2017

published in

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19 September 2017

volume

281

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19 September 2017

issue

1-2

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19 September 2017

page(s)

35-43

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https://scigraph.springernature.com/pub.10.1007/s11010-006-0167-7

19 September 2017

exact match

0 references

cites work

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

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12 December 2020

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

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12 December 2020

Sex is a major determinant of CYP3A4 expression in human liver

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12 December 2020

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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12 December 2020

5' diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site

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12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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12 December 2020

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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12 December 2020

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

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12 December 2020

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

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12 December 2020

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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12 December 2020

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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12 December 2020

Eleven Novel Single Nucleotide Polymorphisms in the NRH2 (PXR) Gene, Pour of which Induce Non-synonymous Amino Acid Alterations

1 reference

12 December 2020

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

12 December 2020

Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

1 reference

12 December 2020

CYP3A genetics in drug metabolism

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12 December 2020

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

12 December 2020

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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12 December 2020

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

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12 December 2020

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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12 December 2020

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

1 reference

12 December 2020

Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

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12 December 2020

Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

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12 December 2020

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

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12 December 2020

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

12 December 2020

Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL

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12 December 2020

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

1 reference

12 December 2020

Sex is a major determinant of CYP3A4 expression in human liver

1 reference

12 December 2020

10.1007/S11010-006-0167-7

Identifiers

DOI

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19 September 2017

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