(Q40351270)

English

Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.

scientific article published on 9 May 2014

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24815013%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24815013%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24815013%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

author name string

Adam G Newman

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24815013%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Philip A Storm

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24815013%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Craig A Townsend

4

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Europe PubMed Central

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18 March 2020

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publication date

9 May 2014

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18 March 2020

Journal of the American Chemical Society

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18 March 2020

136

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18 March 2020

20

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Europe PubMed Central

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18 March 2020

7348-7362

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24815013%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

Thioesterase domains of fungal nonreducing polyketide synthases act as decision gates during combinatorial biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Rational reprogramming of fungal polyketide first-ring cyclization

1 reference

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22 September 2017

Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Natural products as sources of new drugs over the 30 years from 1981 to 2010

1 reference

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22 September 2017

New insights into the formation of fungal aromatic polyketides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis

1 reference

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22 September 2017

Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

1 reference

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22 September 2017

Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans

1 reference

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22 September 2017

Solution structure of an acyl carrier protein domain from a fungal type I polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Revisiting the modularity of modular polyketide synthases

1 reference

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22 September 2017

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

1 reference

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22 September 2017

The crystal structure of a mammalian fatty acid synthase

1 reference

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22 September 2017

Mining and engineering natural-product biosynthetic pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

A polyketide synthase of Plumbago indica that catalyzes the formation of hexaketide pyrones

1 reference

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22 September 2017

Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Combinatorial biosynthesis--potential and problems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Polyketide biosynthesis: a millennium review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Engineering biodiversity with type II polyketide synthase genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

22 September 2017

Deconstruction of iterative multidomain polyketide synthase function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

25 September 2017

Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

17 June 2018

Redirecting the cyclization steps of fungal polyketide synthase.

1 reference

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17 June 2018

Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4046768

17 June 2018

Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase

1 reference

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The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis

1 reference

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Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases

1 reference

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20 August 2018

The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae

1 reference

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20 August 2018

Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans

1 reference

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20 August 2018

1 reference

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20 August 2018

Complex enzymes in microbial natural product biosynthesis, part B: polyketides, aminocoumarins and carbohydrates. Preface

1 reference

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor.

1 reference

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inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

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