(Q40354092)

19 September 2017

Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2. (English)

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19 September 2017

C X Wang

1

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19 September 2017

J H Song

2

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19 September 2017

D K Song

3

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19 September 2017

V W Yong

4

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19 September 2017

A Shuaib

5

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19 September 2017

C Hao

6

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19 September 2017

4 November 2005

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Cell Death & Differentiation

19 September 2017

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19 September 2017

13

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19 September 2017

7

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19 September 2017

1203-1212

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401804

19 September 2017

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cites work

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

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An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

21 January 2018

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Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

21 January 2018

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Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system.

21 January 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

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Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

21 January 2018

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Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

21 January 2018

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Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

21 January 2018

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Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.

21 January 2018

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ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

21 January 2018

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Death receptors: signaling and modulation

21 January 2018

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Mitochondria: releasing power for life and unleashing the machineries of death

21 January 2018

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

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Neurotrophins: roles in neuronal development and function

21 January 2018

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Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

21 January 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

21 January 2018

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Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

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Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

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Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

21 January 2018

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

21 January 2018

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

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Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase.

21 January 2018

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

21 January 2018

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The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

21 January 2018

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Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration

21 January 2018

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7 January 2021

Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.

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7 January 2021

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401804

7 January 2021

Interleukin-1 is a key regulator of matrix metalloproteinase-9 expression in human neurons in culture and following mouse brain trauma in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401804

7 January 2021

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401804

7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401804

7 January 2021

TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401804

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401804

1 reference

Dimensions Publication ID

19 September 2017

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1 reference