(Q40356364)

19 September 2017

title

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation (English)

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19 September 2017

main subject

acute myeloid leukemia

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8

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19 September 2017

12

C M Croce

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19 September 2017

S S Tarighat

1

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19 September 2017

R Santhanam

2

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19 September 2017

D Frankhouser

3

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19 September 2017

H S Radomska

4

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19 September 2017

H Lai

5

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19 September 2017

M Anghelina

6

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19 September 2017

H Wang

7

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19 September 2017

L Alinari

9

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19 September 2017

A Walker

10

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19 September 2017

M A Caligiuri

11

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19 September 2017

L Li

13

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19 September 2017

R Garzon

14

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19 September 2017

C Li

15

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19 September 2017

R A Baiocchi

16

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19 September 2017

G Marcucci

17

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19 September 2017

publication date

5 November 2015

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19 September 2017

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19 September 2017

volume

30

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19 September 2017

issue

4

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19 September 2017

page(s)

789-799

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Genetics of myeloid malignancies: pathogenetic and clinical implications

19 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FLEU.2015.308

21 January 2018

Acute myeloid leukaemia

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https://api.crossref.org/works/10.1038%2FLEU.2015.308

Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Epigenetic mechanisms in AML - a target for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Epigenetics in cancer: targeting chromatin modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Protein arginine methyltransferases and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Interplay between chromatin remodelers and protein arginine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Arginine methylation at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Arginine methylation regulates the p53 response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Arginine methylation an emerging regulator of protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Enhanced arginine methylation of programmed cell death 4 protein during nutrient deprivation promotes tumor cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Evaluation of the performance of four molecular docking programs on a diverse set of protein-ligand complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Negative regulation of transcription by the type II arginine methyltransferase PRMT5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

MicroRNA 29b functions in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Sp1/NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

The role of FLT3 in haematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.308

Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells

21 January 2018

1 reference

12 December 2020

Advances in understanding the biology and genetics of acute myelocytic leukemia

1 reference

12 December 2020

Multiple ligand simultaneous docking: orchestrated dancing of ligands in binding sites of protein

1 reference

12 December 2020

Gene mutation and AML pathogenesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/LEU.2015.308

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Dimensions Publication ID

19 September 2017

1036009391

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1 reference