(Q40358819)

19 September 2017

Transition states of uncatalyzed hydrolysis and aminolysis reactions of a ribosomal P-site substrate determined by kinetic isotope effects (English)

1 reference

19 September 2017

David A Hiller

1

1 reference

19 September 2017

Minghong Zhong

series ordinal

2

1 reference

19 September 2017

Vipender Singh

series ordinal

3

1 reference

19 September 2017

Scott A Strobel

series ordinal

4

1 reference

19 September 2017

language of work or name

English

0 references

publication date

1 May 2010

1 reference

19 September 2017

11

1 reference

inferred from page(s)

published in

Biochemistry

1 reference

19 September 2017

49

1 reference

19 September 2017

18

1 reference

19 September 2017

3868-3878

1 reference

Crystal structure of a translation termination complex formed with release factor RF2

19 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Structural basis for translation termination on the 70S ribosome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

An uncharged amine in the transition state of the ribosomal peptidyl transfer reaction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Synthesis of isotopically labeled P-site substrates for the ribosomal peptidyl transferase reaction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Mechanism of peptide bond synthesis on the ribosome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Kinetic isotope effects in Ras-catalyzed GTP hydrolysis: evidence for a loose transition state

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

The ribosome as an entropy trap

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

An oxocarbenium-ion intermediate of a ribozyme reaction indicated by kinetic isotope effects

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Enzymatic transition state poise and transition state analogues

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Release of peptide promoted by the GGQ motif of class 1 release factors regulates the GTPase activity of RF3.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

The structural basis of ribosome activity in peptide bond synthesis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Calculation of the relative geometry of tRNAs in the ribosome from directed hydroxyl-radical probing data

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Site-directed mutagenesis and the role of the oxyanion hole in subtilisin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

The mechanism of the aminolysis of acetate esters.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Transition-state structures for enzymatic and alkaline phosphotriester hydrolysis.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Transition-state geometry measurements from (13)c isotope effects. The experimental transition state for the epoxidation of alkenes with oxaziridines

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Two distinct components of release factor function uncovered by nucleophile partitioning analysis

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Kinetic isotope effect analysis of the ribosomal peptidyl transferase reaction

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Substrate-assisted catalysis of peptide bond formation by the ribosome

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864349

Analysis of predictions for the catalytic mechanism of ribosomal peptidyl transfer

20 August 2018

1 reference

12 December 2020

Efficient Ribosomal Peptidyl Transfer Critically Relies on the Presence of the Ribose 2‘-OH at A2451 of 23S rRNA

1 reference

12 December 2020

Orientation of ribonucleoside derivatives by proton magentic resonance spectroscopy

1 reference

12 December 2020

Structure of crystalline alpha-chymotrypsin. IV. The structure of indoleacryloyl-alpha-chyotrypsin and its relevance to the hydrolytic mechanism of the enzyme

1 reference

12 December 2020

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1 reference

12 December 2020

Isolation and characterization of a new hydroxamic acid from Pseudomonas mildenbergii

1 reference

12 December 2020

A possible mechanism of peptide bond formation on ribosome without mediation of peptidyl transferase

1 reference

12 December 2020

THE MECHANISM OF HYDROLYSIS OF AMINO ACYL RNA

1 reference

12 December 2020

ON THE SITE OF ESTERIFICATION OF AMINO ACIDS TO SOLUBLE RNA

1 reference

12 December 2020

Synthesis of the ribosomal P-site substrate CCA-pcb

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI901458X

1 reference

19 September 2017

1 reference

19 September 2017

PubMed publication ID

20359191

1 reference