(Q40392908)

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Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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apoptotic process

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1 reference

based on heuristic

inferred from title

insulin secretion involved in cellular response to glucose stimulus

1 reference

based on heuristic

inferred from title

Christian Widmann

7

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

5

object named as

Gérard Waeber

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20 September 2017

Amar Abderrahmani

object named as

Amar Abderrahmani

3

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author name string

Jiang-Yan Yang

1

1 reference

Europe PubMed Central

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20 September 2017

Joël Walicki

2

1 reference

Europe PubMed Central

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20 September 2017

Marion Cornu

4

1 reference

Europe PubMed Central

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20 September 2017

Bernard Thorens

6

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20 September 2017

language of work or name

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publication date

25 July 2005

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20 September 2017

Journal of Biological Chemistry

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20 September 2017

280

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20 September 2017

38

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Europe PubMed Central

PubMed publication ID

20 September 2017

32835-32842

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

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Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

1 reference

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Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Many cuts to ruin: a comprehensive update of caspase substrates

1 reference

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21 January 2018

Cell death: critical control points

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Expression of a dominant negative inhibitor of NF-kappaB protects MIN6 beta-cells from cytokine-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Surviving the kiss of death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Functional analysis of a conditionally transformed pancreatic beta-cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis.

1 reference

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21 January 2018

Agonist-induced internalization and recycling of the glucagon-like peptide-1 receptor in transfected fibroblasts and in insulinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

1 reference

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21 January 2018

Clinical islet transplant: current and future directions towards tolerance

1 reference

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21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504058200

21 January 2018

Identifiers

10.1074/JBC.M504058200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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