(Q40485152)

English

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways (English)

1 reference

Europe PubMed Central

20 September 2017

Nils Billestrup

12

1 reference

Europe PubMed Central

20 September 2017

Thomas Mandrup-Poulsen

object named as

T Mandrup-Poulsen

11

0 references

Flemming Pociot

object named as

F Pociot

9

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author name string

A E Karlsen

1

1 reference

Europe PubMed Central

20 September 2017

P E Heding

2

1 reference

Europe PubMed Central

20 September 2017

H Frobøse

3

1 reference

Europe PubMed Central

20 September 2017

S G Rønn

4

1 reference

Europe PubMed Central

20 September 2017

M Kruhøffer

5

1 reference

Europe PubMed Central

20 September 2017

T F Orntoft

6

1 reference

Europe PubMed Central

20 September 2017

M Darville

7

1 reference

Europe PubMed Central

20 September 2017

D L Eizirik

8

1 reference

Europe PubMed Central

20 September 2017

J Nerup

10

1 reference

Europe PubMed Central

20 September 2017

publication date

1 November 2004

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

47

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Europe PubMed Central

20 September 2017

11

1 reference

Europe PubMed Central

20 September 2017

1998-2011

1 reference

Europe PubMed Central

20 September 2017

https://scigraph.springernature.com/pub.10.1007/s00125-004-1568-3

0 references

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined genome and proteome approach to identify new susceptibility genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target cell expression of suppressor of cytokine signaling-1 prevents diabetes in the NOD mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive parallel gene expression profiling of RINm5F pancreatic islet beta-cells stimulated with interleukin-1beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Ikappa B repressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the pathogenesis of IDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family of cytokine-inducible inhibitors of signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1beta swiftly down-regulates UCP-2 mRNA in beta-cells by mechanisms not directly coupled to toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOCS: physiological suppressors of cytokine signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell maturation leads to in vitro sensitivity to cytotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of an interleukin-1 beta precursor and its conversion to interleukin-1 beta.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytokines in the pathogenesis of autoimmune diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA "fossils" and phylogenetic analysis. Using L1 (LINE-1, long interspersed repeated) DNA to determine the evolutionary history of mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UV light and ionizing radiations cause programmed death of rat chloroleukaemia cells by inducing retropositions of a mobile DNA element (L1Rn).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteome analysis--a novel approach to understand the pathogenesis of Type 1 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suicidal death of rat chloroleukaemia cells by activation of the long interspersed repetitive DNA element (L1Rn)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N omega-nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/E rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatty acids potentiate interleukin-1beta toxicity in the beta-cell line INS-1E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Target sites for the transposition of rat long interspersed repeated DNA elements (LINEs) are not random

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential role of the JNK and p38 MAPK pathway in c-Myc- and s-Myc-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15578154

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-004-1568-3

1 reference

Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

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