(Q40420346)

20 September 2017

A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas (English)

1 reference

20 September 2017

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Masakazu Ogura

1

1 reference

20 September 2017

Toru Shibata

2

1 reference

20 September 2017

Junlin Yi

3

1 reference

20 September 2017

Junye Liu

4

1 reference

20 September 2017

Runjiang Qu

5

1 reference

20 September 2017

Hiroshi Harada

6

1 reference

20 September 2017

Masahiro Hiraoka

7

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20 September 2017

1 May 2005

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20 September 2017

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20 September 2017

96

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20 September 2017

5

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20 September 2017

288-294

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HIF-1 and tumor progression: pathophysiology and therapeutics

20 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Regulation of angiogenesis by hypoxia: role of the HIF system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

HIF hydroxylation and the mammalian oxygen-sensing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1 alpha expression in renal cell carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Development of a hypoxia-responsive vector for tumor-specific gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Tumour suppression by the human von Hippel-Lindau gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Hypoxia-mediated tumour targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

Targeting gene expression to hypoxic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2005.00044.X

10.1111/J.1349-7006.2005.00044.X

21 January 2018

Identifiers

DOI

1 reference

20 September 2017

1 reference