(Q34176439)

31 July 2017

1 reference

title

Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives (English)

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31 July 2017

Greco O

1

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PubMed ID

11241346

31 July 2017

Dachs GU

series ordinal

2

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31 July 2017

1 April 2001

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Journal of Cellular Physiology

31 July 2017

15

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based on heuristic

inferred from page(s)

published in

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31 July 2017

187

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31 July 2017

22-36

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31 July 2017

1

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Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine

31 July 2017

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Alkylation and cleavage of DNA by carbon-centered radical metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte-macrophage colony-stimulating factor gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

A family of bicistronic vectors to enhance both local and systemic antitumor effects of HSVtk or cytokine expression in a murine melanoma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Combination gene therapy for liver metastasis of colon carcinoma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: consequences for HSVtk/GCV anticancer gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Selective cell ablation in transgenic mice expression E. coli nitroreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Long-term survival of immunocompetent rats with intraperitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Suicide genes and bystander killing: local and distant effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Long-term connexin-mediated bystander effect in highly tumorigenic human cells in vivo in herpes simplex virus thymidine kinase/ganciclovir gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The biochemistry and mechanism of action of acyclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Intercellular trafficking and protein delivery by a herpesvirus structural protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Intercellular trafficking of VP22-GFP fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Toward targeted "oxidation therapy" of cancer: peroxidase-catalysed cytotoxicity of indole-3-acetic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Peroxidase-catalyzed effects of indole-3-acetic acid and analogues on lipid membranes, DNA, and mammalian cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Immune system in suicide-gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Actions of HSVtk and connexin43 gene delivery on gap junctional communication and drug sensitization in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The macrophage - a novel system to deliver gene therapy to pathological hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

In situ gene therapy for adenocarcinoma of the prostate: a phase I clinical trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

In vivo efficacy and toxicity of 5-fluorocytosine/cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Adenovirus-mediated combined suicide gene and interleukin-2 gene therapy for the treatment of established tumor and induction of antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Gene therapy of hepatoma: bystander effects and non-apoptotic cell death induced by thymidine kinase and ganciclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Tumour-growth inhibitorynitrofphenylaziridines and related compounds structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Enhancement of tumor ablation by a selected HSV-1 thymidine kinase mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Purified herpes simplex thymidine kinase retroviral particles. II. Influence of clinical parameters and bystander killing mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Differential chemosensitivity of breast cancer cells to ganciclovir treatment following adenovirus-mediated herpes simplex virus thymidine kinase gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The clinical rationale for S-phase radiosensitization in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Self-immolative anthracycline prodrugs for suicide gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Molecular chemotherapy for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Intercellular delivery of functional p53 by the herpesvirus protein VP22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Production and characterization of a bicistronic Moloney-based retroviral vector expressing human interleukin 2 and herpes simplex virus thymidine kinase for gene therapy of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model

21 January 2018

1 reference

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Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line

21 January 2018

1 reference

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Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models

21 January 2018

1 reference

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Gene therapy for glioblastoma [correction of gliobestome] multiform: in vivo tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir

21 January 2018

1 reference

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Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

21 January 2018

1 reference

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Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: implications for gene therapeutic approaches

21 January 2018

1 reference

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Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma

21 January 2018

1 reference

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Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo

21 January 2018

1 reference

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Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression

21 January 2018

1 reference

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Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

21 January 2018

1 reference

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Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene

21 January 2018

1 reference

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Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

The nitroreductase/CB1954 combination in Epstein-Barr virus-positive B-cell lines: induction of bystander killing in vitro and in vivo

21 January 2018

1 reference

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HSV-tk gene therapy in head and neck squamous cell carcinoma. Enhancement by the local and distant bystander effect

21 January 2018

1 reference

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The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

21 January 2018

1 reference

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Targeting gene expression to hypoxic tumor cells

21 January 2018

1 reference

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A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent Glioblastoma

21 January 2018

1 reference

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Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes

21 January 2018

1 reference

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Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity

21 January 2018

1 reference

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Gap junctions: the "kiss of death" and the "kiss of life"

21 January 2018

1 reference

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Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1097-4652%282001%299999%3A9999%3C%3A%3AAID-JCP1060%3E3.0.CO%3B2-H

Transport of 5-fluorouracil and uracil into human erythrocytes

21 January 2018

1 reference

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The treatment of ovarian cancer with a gene modified cancer vaccine: a phase I study

21 January 2018

1 reference

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Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model

21 January 2018

1 reference

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A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

21 January 2018

1 reference

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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase

21 January 2018

1 reference

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Antibody-directed enzyme prodrug therapy: pharmacokinetics and plasma levels of prodrug and drug in a phase I clinical trial

21 January 2018

1 reference

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Hypoglycemic action of indole-3-acetic acid by mouth in patients with diabetes mellitus.

21 January 2018

1 reference

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The immune response elicited by mammary adenocarcinoma cells transduced with interferon-gamma and cytosine deaminase genes cures lung metastases by parental cells

21 January 2018

1 reference

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Peroxidase activity may play a role in the cytotoxic effect of indole acetic acid

21 January 2018

1 reference

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Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

21 January 2018

1 reference

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Analysis of antibody-enzyme conjugate clearance by investigation of prodrug and active drug in an ADEPT clinical study

21 January 2018

1 reference

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10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11241346