(Q40425515)

20 September 2017

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title

The role of beta-amyloid in the development of Alzheimer's disease (English)

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20 September 2017

The Role of β-Amyloid in the Development of Alzheimerʼs Disease (English)

1 reference

10.2165/00002512-199507020-00004

Crossref

DOI

https://api.crossref.org/works/10.2165/00002512-199507020-00004

21 May 2024

0 references

K. Ii

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A7579788

21 May 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=7579788

21 May 2024

publication date

1 August 1995

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20 September 2017

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20 September 2017

7

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20 September 2017

2

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20 September 2017

97-109

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https://scigraph.springernature.com/pub.10.2165/00002512-199507020-00004

20 September 2017

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Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain.

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The Alzheimer amyloid precursor-related transcript lacking the beta/A4 sequence is specifically increased in Alzheimer's disease brain

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The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Role of the beta-amyloid precursor protein in Alzheimer's disease.

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12 December 2020

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Widespread serum amyloid P immunoreactivity in cortical amyloid deposits and the neurofibrillary pathology of Alzheimer's disease and other degenerative disorders

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Distribution pattern and functional state of alpha 1-antichymotrypsin in plaques and vascular amyloid in Alzheimer's disease. A immunohistochemical study with monoclonal antibodies against native and inactivated alpha 1-antichymotrypsin

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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Mechanisms of amyloid deposition in Alzheimer's disease.

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

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Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease

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The spatial patterns of beta/A4 deposit subtypes in Down's syndrome

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Mutation in codon 713 of the β amyloid precursor protein gene presenting with schizophrenia

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Down syndrome due to de novo Robertsonian translocation t(14q;21q): DNA polymorphism analysis suggests that the origin of the extra 21q is maternal

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A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles

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12 December 2020

Detection of point mutations in codon 331 of mitochondrial NADH dehydrogenase subunit 2 in Alzheimer's brains

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Antigenic expression of cathepsin B in aged human brain.

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12 December 2020

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid

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12 December 2020

Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin

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12 December 2020

Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders

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Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie

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12 December 2020

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

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12 December 2020

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

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12 December 2020

Accumulation of inactive cathepsin D in old rats

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12 December 2020

Cystatin A-like immunoreactivity is widely distributed in human brain and accumulates in neuritic plaques of Alzheimer disease subjects.

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12 December 2020

The ubiquitin system for protein degradation

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12 December 2020

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.

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12 December 2020

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

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12 December 2020

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

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12 December 2020

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

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12 December 2020

Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts

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12 December 2020

Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia

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12 December 2020

Alzheimer's disease and amyloid

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12 December 2020

Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease

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12 December 2020

A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution

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12 December 2020

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.

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12 December 2020

Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

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12 December 2020

Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor

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12 December 2020

Overexpression of amyloid precursor protein A4 (beta-amyloid) immunoreactivity in genetically transformed cells: implications for a cellular model of Alzheimer amyloidosis

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12 December 2020

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12 December 2020

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12 December 2020

Search for the genes responsible for familial Alzheimer's disease

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12 December 2020

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12 December 2020

Ubiquitin in neurodegenerative diseases

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12 December 2020

Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.

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12 December 2020

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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12 December 2020

Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor

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12 December 2020

Alzheimer's debate boils over

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12 December 2020

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

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12 December 2020

Alpha 1-antitrypsin and alpha 1-antichymotrypsin are in the lesions of Alzheimer's disease.

1 reference

12 December 2020

Spectrum of morphological appearance of amyloid deposits in Alzheimer's disease

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12 December 2020

Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease

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12 December 2020

Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease

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12 December 2020

The inheritance of Alzheimer's disease: a new interpretation.

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12 December 2020

Acid phosphatase activity in senile plaques and cerebrospinal fluid of patients with Alzheimer's disease.

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12 December 2020

Alzheimer's disease. In search of the soluble

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

12 December 2020

Ultrastructural observations on neuronal lipofuscin (age pigment) and dense bodies induced by a proteinase inhibitor, leupeptin, in rat hippocampus.

1 reference

12 December 2020

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

12 December 2020

Alpha 1-trypsin immunoreactivity in Alzheimer disease.

1 reference

12 December 2020

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

1 reference

12 December 2020

Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors

1 reference

12 December 2020

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

1 reference

12 December 2020

Purification and characterization of the 26S proteasome complex catalyzing ATP-dependent breakdown of ubiquitin-ligated proteins from rat liver

1 reference

12 December 2020

Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14

1 reference

12 December 2020

Aging, amyloid, and Alzheimer's disease

1 reference

12 December 2020

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1 reference

12 December 2020

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

12 December 2020

Major Setback for Alzheimer's Models

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12 December 2020

RETRACTED ARTICLE: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor protein

1 reference

12 December 2020

Determination of amyloid beta protein precursors harboring active form of proteinase inhibitor domains in cerebrospinal fluid of Alzheimer's disease patients by trypsin-antibody sandwich ELISA.

1 reference

12 December 2020

Preamyloid Deposits, Amyloid Deposits, and Senile Plaques in Alzheimer's Disease, Down Syndrome, and Aging

1 reference

12 December 2020

Lysosome instability in aged rat brain

1 reference

12 December 2020

Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme

1 reference

12 December 2020

Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases

1 reference

12 December 2020

Change in membrane permeability induced by amyloid beta-protein fragment 25-35 in brain neurons dissociated from rats

1 reference

12 December 2020

Degradation of neurofilament proteins by purified human brain cathepsin D.

1 reference

12 December 2020

Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease

1 reference

12 December 2020

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

1 reference

12 December 2020

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

1 reference

12 December 2020

Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type.

1 reference

12 December 2020

1 reference

12 December 2020

Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

1 reference

12 December 2020

A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor.

1 reference

12 December 2020

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

1 reference

12 December 2020

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1 reference

12 December 2020

A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition.

1 reference

12 December 2020

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

12 December 2020

Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain

1 reference

12 December 2020

A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein

1 reference

12 December 2020

Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases

1 reference

12 December 2020

Ubiquitin is a component of paired helical filaments in Alzheimer's disease.

1 reference

12 December 2020

A comparison of familial and sporadic Alzheimer's disease.

1 reference

12 December 2020

10.2165/00002512-199507020-00004

Identifiers

DOI

1 reference

Dimensions Publication ID

20 September 2017

0 references

1 reference