(Q40442297)

20 September 2017

title

Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells (English)

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20 September 2017

3

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20 September 2017

author name string

Sivanandhan Dhanalakshmi

series ordinal

1

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20 September 2017

Chapla Agarwal

series ordinal

2

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20 September 2017

Rajesh Agarwal

series ordinal

4

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20 September 2017

language of work or name

English

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publication date

25 March 2005

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Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

21

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20 September 2017

page(s)

20375-20383

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UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression

20 September 2017

cites work

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Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis

21 January 2018

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Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes

21 January 2018

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Silibinin modulates UVB-induced apoptosis via mitochondrial proteins, caspases activation, and mitogen-activated protein kinase signaling in human epidermoid carcinoma A431 cells

21 January 2018

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Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling

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ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

21 January 2018

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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Role of DNA-PK in the cellular response to DNA double-strand breaks

21 January 2018

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The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

21 January 2018

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Solar ultraviolet radiation as a trigger of cell signal transduction

21 January 2018

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Involvement of MAP kinase signal transduction pathway in UVB-induced activation of macrophages in vitro.

21 January 2018

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Shortage of mitogen-activated protein kinase is responsible for resistance to AP-1 transactivation and transformation in mouse JB6 cells.

21 January 2018

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ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

21 January 2018

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Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells

21 January 2018

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PI3K/Akt and apoptosis: size matters

21 January 2018

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21 January 2018

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Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds

21 January 2018

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Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines

21 January 2018

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Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

21 January 2018

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Regulation of p53 in response to DNA damage

21 January 2018

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

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Tissue distribution of silibinin, the major active constituent of silymarin, in mice and its association with enhancement of phase II enzymes: implications in cancer chemoprevention.

21 January 2018

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Flavonoid antioxidant silymarin and skin cancer

21 January 2018

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

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Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin

21 January 2018

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Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

21 January 2018

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Molecular mechanisms of UV-induced apoptosis

21 January 2018

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21 January 2018

UV-induced skin damage

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MAPKs mediate S phase arrest induced by vanadate through a p53-dependent pathway in mouse epidermal C141 cells

21 January 2018

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

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Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

21 January 2018

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Exposure to asphalt fumes activates activator protein-1 through the phosphatidylinositol 3-Kinase/Akt signaling pathway in mouse epidermal cells

21 January 2018

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Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice

21 January 2018

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Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes

21 January 2018

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Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1.

21 January 2018

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The DNA-dependent protein kinase

21 January 2018

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Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

21 January 2018

1 reference

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DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage

21 January 2018

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DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

21 January 2018

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Green tea polyphenol epigallocatechin-3 gallate induces apoptosis of proliferating vascular smooth muscle cells via activation of p53.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M414640200

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20 September 2017

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