(Q40594004)

21 September 2017

title

DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage (English)

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21 September 2017

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Melissa T Jack

1

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21 September 2017

Richard A Woo

2

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21 September 2017

Noboru Motoyama

3

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21 September 2017

Hitoyuki Takai

4

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21 September 2017

Patrick W K Lee

5

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21 September 2017

language of work or name

English

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publication date

29 January 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

15

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21 September 2017

page(s)

15269-15273

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 September 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M309917200

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Questioning the role of checkpoint kinase 2 in the p53 DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

p53-dependent apoptosis suppresses tumor growth and progression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309917200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309917200

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release_su76otqybzektnvl4oxlvcmtc4

21 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/su76otqybzektnvl4oxlvcmtc4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference