(Q40453583)

English

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.

scientific article published on April 2005

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scholarly article

1 reference

Europe PubMed Central

20 September 2017

HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. (English)

1 reference

Europe PubMed Central

20 September 2017

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Stephanie S. Watowich

6

1 reference

Europe PubMed Central

20 September 2017

Gregg L. Semenza

4

object named as

Gregg L Semenza

1 reference

Europe PubMed Central

20 September 2017

author name string

Michael J Gray

1

1 reference

Europe PubMed Central

20 September 2017

Jing Zhang

2

1 reference

Europe PubMed Central

20 September 2017

Lee M Ellis

3

1 reference

Europe PubMed Central

20 September 2017

Douglas B Evans

5

1 reference

Europe PubMed Central

20 September 2017

Gary E Gallick

7

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Europe PubMed Central

20 September 2017

language of work or name

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publication date

1 April 2005

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Europe PubMed Central

20 September 2017

1 reference

Europe PubMed Central

20 September 2017

24

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Europe PubMed Central

20 September 2017

3110-3120

1 reference

Europe PubMed Central

20 September 2017

19

1 reference

Europe PubMed Central

20 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208513

0 references

Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

1 reference

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7 January 2021

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An essential role for p300/CBP in the cellular response to hypoxia

1 reference

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7 January 2021

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Hypoxia-inducible factor-1 and oncogenic signalling

1 reference

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7 January 2021

based on heuristic

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The role of STATs in transcriptional control and their impact on cellular function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

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Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer

1 reference

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7 January 2021

based on heuristic

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

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Angiogenesis and metastasis

1 reference

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7 January 2021

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Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src

1 reference

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7 January 2021

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Hypoxic Regulation of Lactate Dehydrogenase A

1 reference

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7 January 2021

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Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase

1 reference

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7 January 2021

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A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma.

1 reference

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7 January 2021

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Molecular mechanism of hypoxia-inducible factor 1alpha -p300 interaction. A leucine-rich interface regulated by a single cysteine

1 reference

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7 January 2021

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Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

1 reference

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7 January 2021

based on heuristic

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

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7 January 2021

based on heuristic

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Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer

1 reference

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7 January 2021

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular endothelial growth factor (VEGF) expression in prostate cancer and benign prostatic hyperplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

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Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular endothelial growth factor is a secreted angiogenic mitogen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

c-Src activates the DNA binding and transcriptional activity of Stat3 molecules: serine 727 is not required for transcriptional activation under certain circumstances

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

1 reference

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7 January 2021

based on heuristic

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Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Human p300 protein is a coactivator for the transcription factor MyoD

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208513

7 January 2021

based on heuristic

inferred from DOI database lookup

Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation.

1 reference

12 October 2022

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Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

1 reference

12 October 2022

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Activation and association of Stat3 with Src in v-Src-transformed cell lines

1 reference

12 October 2022

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1038/SJ.ONC.1208513

Src family kinases in tumor progression and metastasis

1 reference

12 October 2022

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STAT proteins: From normal control of cellular events to tumorigenesis

1 reference

12 October 2022

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Targeting HIF-1 for cancer therapy

1 reference

12 October 2022

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Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer

1 reference

12 October 2022

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Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells

1 reference

12 October 2022

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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

1 reference

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Role of angiogenesis in tumor growth and metastasis

1 reference

12 October 2022

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Stat3 activation by Src induces specific gene regulation and is required for cell transformation

1 reference

12 October 2022

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Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability

1 reference

12 October 2022

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Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1 reference

12 October 2022

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Vascular endothelial growth factor (VEGF) expression and survival in human epithelial ovarian carcinomas

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Hypoxia--a key regulatory factor in tumour growth

1 reference

12 October 2022

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Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

1 reference

12 October 2022

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Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma

1 reference

12 October 2022

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Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene

1 reference

12 October 2022

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Stat3 activation is required for cellular transformation by v-src

1 reference

12 October 2022

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Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

1 reference

12 October 2022

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Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription

1 reference

12 October 2022

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10.1038/SJ.ONC.1208513

1 reference

Europe PubMed Central

20 September 2017

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1 reference

Europe PubMed Central

20 September 2017

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