(Q40461412)

20 September 2017

title

A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing. (English)

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20 September 2017

Pancham Bakshi

1

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20 September 2017

Yung-Feng Liao

2

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20 September 2017

Jun Gao

3

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20 September 2017

Jake Ni

4

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20 September 2017

Ross Stein

5

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20 September 2017

Li-An Yeh

6

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20 September 2017

Michael S Wolfe

7

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20 September 2017

publication date

1 February 2005

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Journal of Biomolecular Screening

20 September 2017

published in

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20 September 2017

volume

10

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20 September 2017

issue

1

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20 September 2017

page(s)

1-12

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Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

20 September 2017

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The C-terminus of the beta protein is critical in amyloidogenesis

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

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21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

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21 January 2018

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21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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A detergent-insoluble membrane compartment contains A beta in vivo

21 January 2018

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Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase

21 January 2018

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

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Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells

21 January 2018

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21 January 2018

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

21 January 2018

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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

21 January 2018

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21 January 2018

Identifiers

DOI

10.1177/1087057104270068

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20 September 2017

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