(Q40465500)

English

Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical.

scientific article published on February 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical. (English)

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Lactobacillus leichmannii

object named as

Lactobacillus leichmannii

1 reference

based on heuristic

inferred from title

3

object named as

Joanne Stubbe

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

author name string

Gregory J S Lohman

1

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Gary J Gerfen

2

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

language of work or name

0 references

publication date

1 February 2010

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

49

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

1396-1403

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Treatment of advanced pancreatic cancer: from gemcitabine single agent to combinations and targeted therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Pharmacogenomics of gemcitabine in non-small-cell lung cancer and other solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Radical sites in Mycobacterium tuberculosis KatG identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electron transfer couplings

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Ribonucleotide reductases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Factors modulating conformational equilibria in large modular proteins: a case study with cobalamin-dependent methionine synthase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

The crystal structure of class II ribonucleotide reductase reveals how an allosterically regulated monomer mimics a dimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Structure and function of the radical enzyme ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Harnessing free radicals: formation and function of the tyrosyl radical in ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

Fluorinated substrate analogs: routes of metabolism and selective toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

22 September 2017

2'-Deoxy-2'-halonucleotides as alternate substrates and mechanism-based inactivators of Lactobacillus leichmannii ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

25 September 2017

Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

17 June 2018

Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

17 June 2018

Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

17 June 2018

Insights into the hydrogen-abstraction reactions of diol dehydratase: relevance to the catalytic mechanism and suicide inactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

20 August 2018

Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

20 August 2018

Analysis of the tuning and operation of reflection resonator EPR spectrometers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

20 August 2018

Identification of cis-ethanesemidione as the organic radical derived from glycolaldehyde in the suicide inactivation of dioldehydrase and of ethanolamine ammonia-lyase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2867335

20 August 2018

Studies on the catalysis of carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: evidence for concerted carbon-cobalt bond homolysis and thiyl radical formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribonucleotide reductases: radical enzymes with suicidal tendencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of inactivation of Escherichia coli and Lactobacillus leichmannii ribonucleotide reductases by 2'-chloro-2'-deoxynucleotides: evidence for generation of 2-methylene-3(2H)-furanone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coenzyme B12-dependent ribonucleotide reductase: evidence for the participation of five cysteine residues in ribonucleotide reduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein Radicals in Enzyme Catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermodynamic and kinetic studies on carbon-cobalt bond homolysis by ribonucleoside triphosphate reductase: the importance of entropy in catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20088568

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI9021318

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

1 reference

Europe PubMed Central

PMC publication ID

20 September 2017

ResearchGate publication ID

0 references

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