(Q42568349)

English

Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant

scientific article published on December 2009

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scholarly article

1 reference

Europe PubMed Central

2 November 2017

Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant (English)

1 reference

Europe PubMed Central

2 November 2017

8

object named as

JoAnne Stubbe

1 reference

Europe PubMed Central

2 November 2017

Robert G. Griffin

6

object named as

Robert G Griffin

1 reference

Europe PubMed Central

2 November 2017

author name string

Erin Artin

1

1 reference

Europe PubMed Central

2 November 2017

Jun Wang

2

1 reference

Europe PubMed Central

2 November 2017

Gregory J S Lohman

3

1 reference

Europe PubMed Central

2 November 2017

Kenichi Yokoyama

4

1 reference

Europe PubMed Central

2 November 2017

Guixue Yu

5

1 reference

Europe PubMed Central

2 November 2017

Galit Bar

7

1 reference

Europe PubMed Central

2 November 2017

language of work or name

0 references

publication date

1 December 2009

1 reference

Europe PubMed Central

2 November 2017

1 reference

Europe PubMed Central

2 November 2017

48

1 reference

Europe PubMed Central

2 November 2017

49

1 reference

Europe PubMed Central

2 November 2017

11622-11629

1 reference

Europe PubMed Central

2 November 2017

Inactivation of Lactobacillus leichmannii ribonucleotide reductase by 2',2'-difluoro-2'-deoxycytidine 5'-triphosphate: adenosylcobalamin destruction and formation of a nucleotide-based radical.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Structure of the nucleotide radical formed during reaction of CDP/TTP with the E441Q-alpha2beta2 of E. coli ribonucleotide reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Understanding ribonucleotide reductase inactivation by gemcitabine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

High-field EPR detection of a disulfide radical anion in the reduction of cytidine 5'-diphosphate by the E441Q R1 mutant of Escherichia coli ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Mammalian deoxyribonucleoside kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Erythrocytic nucleoside diphosphokinase. IV. Evidence for electrophoretic heterogeneity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Direct cloning of the trxB gene that encodes thioredoxin reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Metabolism and action of 2',2'-difluorodeoxycytidine: self-potentiation of cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Interaction of C225SR1 mutant subunit of ribonucleotide reductase with R2 and nucleoside diphosphates: tales of a suicidal enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

Site-directed mutagenesis and deletion of the carboxyl terminus of Escherichia coli ribonucleotide reductase protein R2. Effects on catalytic activity and subunit interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

28 May 2018

EasySpin, a comprehensive software package for spectral simulation and analysis in EPR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

16 August 2018

Mechanism for ribonucleotide reductase inactivation by the anticancer drug gemcitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

16 August 2018

Generation of the R2 subunit of ribonucleotide reductase by intein chemistry: insertion of 3-nitrotyrosine at residue 356 as a probe of the radical initiation process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

16 August 2018

Pre-steady-state and steady-state kinetic analysis of E. coli class I ribonucleotide reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

16 August 2018

Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of E. coli ribonucleotide reductase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917094

16 August 2018

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid assay for CDP reductase activity in mammalian cell extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pulsed electron-nuclear double resonance (ENDOR) at 140 GHz

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoride, pyrophosphate, and base release from 2'-deoxy-2'-fluoronucleoside 5'-diphosphates by ribonucleoside-diphosphate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribonucleotide reductases: radical enzymes with suicidal tendencies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gemcitabine 5'-triphosphate is a stoichiometric mechanism-based inhibitor of Lactobacillus leichmannii ribonucleoside triphosphate reductase: evidence for thiyl radical-mediated nucleotide radical formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein Radicals in Enzyme Catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amplification and purification of plasmid-encoded thioredoxin from Escherichia coli K12

1 reference

https://pubmed.ncbi.nlm.nih.gov/19899770

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI901590Q

1 reference

Europe PubMed Central

2 November 2017

1 reference

Europe PubMed Central

2 November 2017

1 reference

Europe PubMed Central

2 November 2017

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