(Q40478610)

20 September 2017

title

Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. (English)

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20 September 2017

Hua Zhou

1

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20 September 2017

Randall H Kramer

series ordinal

2

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20 September 2017

language of work or name

English

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publication date

17 December 2004

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Journal of Biological Chemistry

20 September 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

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20 September 2017

volume

280

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20 September 2017

issue

11

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20 September 2017

page(s)

10624-10635

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Cell migration: a physically integrated molecular process

20 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

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Rho GTPases control polarity, protrusion, and adhesion during cell movement

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Cell migration: integrating signals from front to back

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RhoA function in lamellae formation and migration is regulated by the alpha6beta4 integrin and cAMP metabolism

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

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A role for Rac in Tiam1-induced membrane ruffling and invasion

21 January 2018

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Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway

21 January 2018

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RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity

21 January 2018

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

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Activation of Rac and Cdc42 by integrins mediates cell spreading

21 January 2018

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Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases

21 January 2018

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Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8.

21 January 2018

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Alpha4beta1 integrin/ligand interaction inhibits alpha5beta1-induced stress fibers and focal adhesions via down-regulation of RhoA and induces melanoma cell migration

21 January 2018

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Integrin signaling to the actin cytoskeleton.

21 January 2018

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Integrin alpha3beta1 engagement disrupts intercellular adhesion

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Alpha7 integrin mediates cell adhesion and migration on specific laminin isoforms

21 January 2018

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Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.

21 January 2018

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Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

21 January 2018

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Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion

21 January 2018

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Distinct involvement of cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH3T3 cells

21 January 2018

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Disruption of Rho signal transduction upon cell detachment

21 January 2018

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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

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21 January 2018

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Modulation of in vivo migratory function of alpha 2 beta 1 integrin in mouse liver

21 January 2018

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Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

21 January 2018

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Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

21 January 2018

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Regulation of integrin-mediated adhesion during cell migration

21 January 2018

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Kinetic model for integrin-mediated adhesion release during cell migration.

21 January 2018

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

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Src family kinases are required for integrin but not PDGFR signal transduction.

21 January 2018

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The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

21 January 2018

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

21 January 2018

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RhoA and ROCK promote migration by limiting membrane protrusions

21 January 2018

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A role for Cdc42 in macrophage chemotaxis

21 January 2018

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Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

21 January 2018

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Mechanics of cell spreading: role of myosin II.

21 January 2018

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Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreading

21 January 2018

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Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells

21 January 2018

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Tenascin-C suppresses Rho activation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411900200

Integrins regulate Rac targeting by internalization of membrane domains

21 January 2018

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Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling

21 January 2018

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Sensing the environment: a historical perspective on integrin signal transduction

21 January 2018

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Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases

21 January 2018

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Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

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Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

21 January 2018

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Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

21 January 2018

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Interplay between Rac and Rho in the control of substrate contact dynamics

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411900200

Integrin alpha3beta1 directs the stabilization of a polarized lamellipodium in epithelial cells through activation of Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M411900200

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Form and function: the laminin family of heterotrimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Laminin isoforms in tumor invasion, angiogenesis and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Integrin alpha3beta1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Cell motility mediated by rho and rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

Ligation of integrin alpha 3beta 1 by laminin 5 at the wound edge activates Rho-dependent adhesion of leading keratinocytes on collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M411900200

21 January 2018

Identifiers

DOI

10.1074/JBC.M411900200

1 reference

20 September 2017

1 reference