(Q52102307)

22 April 2018

title

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. (English)

1 reference

22 April 2018

author name string

Zhong Li

1

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22 April 2018

Michael Hannigan

2

1 reference

22 April 2018

Zhicheng Mo

3

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22 April 2018

Bo Liu

4

1 reference

22 April 2018

Wei Lu

5

1 reference

22 April 2018

Yue Wu

6

1 reference

22 April 2018

Alan V Smrcka

7

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22 April 2018

Guanqing Wu

8

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22 April 2018

Lin Li

9

1 reference

22 April 2018

Mingyao Liu

10

1 reference

22 April 2018

Chi-Kuang Huang

11

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22 April 2018

Dianqing Wu

12

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22 April 2018

language of work or name

English

0 references

publication date

1 July 2003

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22 April 2018

published in

Cell

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22 April 2018

volume

114

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22 April 2018

page(s)

215-227

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22 April 2018

issue

2

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22 April 2018

A role for Cdc42 in macrophage chemotaxis

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Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils

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Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases

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The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

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Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

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Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

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Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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A cell's sense of direction

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7 January 2021

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

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7 January 2021

Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products

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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

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The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

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7 January 2021

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

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7 January 2021

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

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7 January 2021

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Genomic structure of human alpha-pix, and variable deletions in a poly (T) tract in gastric cancer tissue

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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

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7 January 2021

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

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7 January 2021

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

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7 January 2021

Orientation chamber in chemotaxis

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7 January 2021

10.1016/S0092-8674(03)00559-2

Identifiers

DOI

1 reference

22 April 2018

PubMed ID

12887923

1 reference

22 April 2018