(Q40485863)

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Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes

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Europe PubMed Central

PubMed publication ID

20 September 2017

Interleukin-18 is a pro-hypertrophic cytokine that acts through a phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling pathway in cardiomyocytes (English)

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Europe PubMed Central

PubMed publication ID

20 September 2017

4

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Europe PubMed Central

PubMed publication ID

20 September 2017

5

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Mona Nemer

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Europe PubMed Central

PubMed publication ID

20 September 2017

author name string

Bysani Chandrasekar

1

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Europe PubMed Central

PubMed publication ID

20 September 2017

Srinivas Mummidi

2

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Europe PubMed Central

PubMed publication ID

20 September 2017

William C Claycomb

3

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Europe PubMed Central

PubMed publication ID

20 September 2017

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publication date

1 December 2004

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Europe PubMed Central

PubMed publication ID

20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

20 September 2017

280

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Europe PubMed Central

PubMed publication ID

20 September 2017

6

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Europe PubMed Central

PubMed publication ID

20 September 2017

4553-4567

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Europe PubMed Central

PubMed publication ID

20 September 2017

The Genetic Basis for Cardiomyopathy

1 reference

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Left ventricular hypertrophy: pathogenesis, detection, and prognosis

1 reference

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The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism

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Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart

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The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors

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Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

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An early haematopoietic defect in mice lacking the transcription factor GATA-2

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The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.

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The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

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Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity

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Interleukin-18.

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Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death

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Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta

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Beta-adrenergic cardiac hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart.

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HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte

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CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation

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Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR, PI3K, Akt, IKK, and NF-kappaB.

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Epidermal growth factor up-regulates expression of transforming growth factor beta receptor type II in human dermal fibroblasts by phosphoinositide 3-kinase/Akt signaling pathway: Resistance to epidermal growth factor stimulation in scleroderma fibr

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A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

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Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation

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IL-18 and IL-12 Signal Through the NF-κB Pathway to Induce NK-1R Expression on T Cells

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A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways

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Differences in signaling pathways by IL-1beta and IL-18.

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Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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21 January 2018

A20 is dynamically regulated in the heart and inhibits the hypertrophic response

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Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes

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Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy

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Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy

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The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

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Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

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21 January 2018

Cis-acting sequences that modulate atrial natriuretic factor gene expression

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Interleukin-18 up-regulates osteoprotegerin expression in stromal/osteoblastic cells

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Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway

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Purification and characterization of the human interleukin-18 receptor

1 reference

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Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1.

1 reference

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Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling

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Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)

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p70 S6 kinase: an enigma with variations

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

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Cellular survival: a play in three Akts

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Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA

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Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes

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Endotoxin and tumor necrosis factor alpha exert a similar proinflammatory effect in neonatal rat cardiomyocytes, but have different cardiodepressant profiles

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Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart

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Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function

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Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells

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Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

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Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

1 reference

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

1 reference

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Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

1 reference

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Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.

1 reference

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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Identifiers

10.1074/JBC.M411787200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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