(Q40562808)

English

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells

scientific article published on September 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1 reference

based on heuristic

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1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

A M Martelli

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

P L Tazzari

2

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

G Tabellini

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

R Bortul

4

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

A M Billi

5

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

L Manzoli

6

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

A Ruggeri

7

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

R Conte

8

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

L Cocco

9

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

publication date

1 September 2003

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

17

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1794-1805

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.leu.2403044

0 references

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1 reference

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Low relapse rate in children with acute lymphoblastic leukemia after risk-directed therapy

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Induction of apoptosis by cancer chemotherapy.

1 reference

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Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

1 reference

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Molecular signals in anti-apoptotic survival pathways.

1 reference

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Retinoic acid resistance in acute promyelocytic leukemia

1 reference

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Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

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The protein kinase B/Akt signalling pathway in human malignancy

1 reference

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Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

1 reference

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Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

1 reference

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21 January 2018

Involvement of the pathway phosphatidylinositol-3-kinase/AKT-1 in the establishment of the survival response to ionizing radiation.

1 reference

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21 January 2018

Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications

1 reference

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Synthesis and function of 3-phosphorylated inositol lipids

1 reference

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Insulin signaling pathways in time and space.

1 reference

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Flow cytometric detection of total and serine 473 phosphorylated Akt.

1 reference

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Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation

1 reference

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Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1 reference

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The biochemistry of apoptosis

1 reference

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PTEN: life as a tumor suppressor

1 reference

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

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21 January 2018

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

1 reference

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Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

1 reference

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The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells

1 reference

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

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21 January 2018

The modular phosphorylation and activation of p70s6k.

1 reference

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21 January 2018

Phosphorylation and activation of p70s6k by PDK1

1 reference

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

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Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

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Etoposide-mediated deregulation of the G2M checkpoint in myeloid leukaemic cell lines results in loss of cell survival

1 reference

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Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP.

1 reference

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21 January 2018

The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines.

1 reference

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21 January 2018

Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors

1 reference

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21 January 2018

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

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Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

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Mutational analysis of the tumour suppressor gene MMAC1/PTEN in malignant myeloid disorders

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Mutation analysis of PTEN/MMAC1 in acute myeloid leukemia

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Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.

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Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

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How do inhibitory phosphatases work?

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Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

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Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

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Acute myeloid leukemia in adults

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3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

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Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation

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Herbimycin A accelerates the induction of apoptosis following etoposide treatment or γ-irradiation of bcr/abl-positive leukaemia cells

1 reference

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Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Ad

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10.1038/SJ.LEU.2403044

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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release_46vsukwmpbhnnlh5o2glkx6ze4

1 reference

https://api.fatcat.wiki/v0/release/46vsukwmpbhnnlh5o2glkx6ze4

24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

ResearchGate publication ID

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