(Q40486256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

title

Unexpected side chain effects at residue 8 of cyclosporin a derivatives allow photoswitching of immunosuppression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Mike Schutkowski

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

author name string

Yixin Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Frank Erdmann

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Gunter Fischer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

language of work or name

English

0 references

publication date

30 November 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

5 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

280

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

issue

6

1 reference

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5 January 2020

page(s)

4842-4850

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15572368%20AND%20SRC:MED&resulttype=core&format=json

Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

5 January 2020

cites work

1 reference

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

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The mechanism of action of cyclosporin A and FK506

21 January 2018

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Nucleocytoplasmic shuttling and the control of NF-AT signaling

21 January 2018

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Calcineurin. Structure, function, and inhibition

21 January 2018

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Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Sanglifehrin A, a novel cyclophilin-binding immunosuppressant, inhibits IL-2-dependent T cell proliferation at the G1 phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NFkappa B-dependent activation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes

21 January 2018

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Functional association of cyclophilin A with HIV-1 virions

21 January 2018

1 reference

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Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression.

21 January 2018

1 reference

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

21 January 2018

1 reference

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Controlling cell chemistry with caged compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Reversible inhibition of calcineurin by the polyphenolic aldehyde gossypol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Antigen-specific cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Sanglifehrin A, a novel cyclophilin-binding compound showing immunosuppressive activity with a new mechanism of action

21 January 2018

1 reference

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Interactions of cyclosporines with lipid membranes as studied by solid-state nuclear magnetic resonance spectroscopy and high-sensitivity titration calorimetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin.cyclosporin A complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

X-ray structure of a monomeric cyclophilin A-cyclosporin A crystal complex at 2.1 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Thermodynamic characterization of the interaction of human cyclophilin 18 with cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Manipulating immune responses with immunosuppressive agents that target NFAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

Absconding with the Chaperone: Essential Cyclophilin–Gag Interaction in HIV-1 Virions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409178200

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

21 January 2018

1 reference

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