(Q40491362)

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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion

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Europe PubMed Central

PubMed publication ID

21 September 2017

Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion (English)

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Europe PubMed Central

PubMed publication ID

21 September 2017

mouse insulinoma

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Corentin Cras-Méneur

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Corentin Cras-Méneur

2

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Dan S Luciani

6

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Mitsuru Ohsugi

1

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Europe PubMed Central

PubMed publication ID

21 September 2017

Yiyong Zhou

3

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Europe PubMed Central

PubMed publication ID

21 September 2017

Ernesto Bernal-Mizrachi

4

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Europe PubMed Central

PubMed publication ID

21 September 2017

James D Johnson

5

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Europe PubMed Central

PubMed publication ID

21 September 2017

Kenneth S Polonsky

7

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Europe PubMed Central

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21 September 2017

M Alan Permutt

8

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Europe PubMed Central

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21 September 2017

language of work or name

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publication date

15 November 2004

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Europe PubMed Central

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21 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

21 September 2017

280

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Europe PubMed Central

PubMed publication ID

21 September 2017

6

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Europe PubMed Central

PubMed publication ID

21 September 2017

4992-5003

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Europe PubMed Central

PubMed publication ID

21 September 2017

Diabetes mellitus and genetically programmed defects in beta-cell function

1 reference

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21 January 2018

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

1 reference

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21 January 2018

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediat

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21 January 2018

Glucose-induced insulin receptor tyrosine phosphorylation in insulin-secreting beta-cells

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21 January 2018

Insulin feedback action on pancreatic beta-cell function

1 reference

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21 January 2018

Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity

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21 January 2018

Insulin receptor activation inhibits insulin secretion from human islets of Langerhans

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21 January 2018

Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

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Insulin-stimulated insulin secretion in single pancreatic beta cells.

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21 January 2018

Insulin constitutively secreted by beta-cells is necessary for glucose-stimulated insulin secretion

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21 January 2018

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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21 January 2018

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

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21 January 2018

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

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Disruption of IRS-2 causes type 2 diabetes in mice

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21 January 2018

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin

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A system for stable expression of short interfering RNAs in mammalian cells

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Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

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SAGE identification of gene transcripts with profiles unique to pluripotent mouse R1 embryonic stem cells.

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21 January 2018

Transcriptional program of the endocrine pancreas in mice and humans.

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Microarray data normalization and transformation

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Ratio statistics of gene expression levels and applications to microarray data analysis

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21 January 2018

Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line

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21 January 2018

Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice

1 reference

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21 January 2018

Basic local alignment search tool

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21 January 2018

Database resources of the National Center for Biotechnology Information: 2002 update

1 reference

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21 January 2018

SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data

1 reference

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21 January 2018

Gene ontology: tool for the unification of biology

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21 January 2018

Genesis: cluster analysis of microarray data

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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21 January 2018

The dynamic process of apoptosis analyzed by flow cytometry using Annexin-V/propidium iodide and a modified in situ end labeling technique

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21 January 2018

Increased islet apoptosis in Pdx1+/- mice

1 reference

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21 January 2018

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

1 reference

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21 January 2018

Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells

1 reference

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21 January 2018

Cellular survival: a play in three Akts

1 reference

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21 January 2018

Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells

1 reference

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21 January 2018

Activation of serum response factor in the depolarization induction of Egr-1 transcription in pancreatic islet beta-cells

1 reference

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21 January 2018

Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells

1 reference

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21 January 2018

Gene expression cascades in pancreatic development

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Expression of the receptor tyrosine kinase KIT in mature beta-cells and in the pancreas in development

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Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

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Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.

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Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells

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Insulin activates ATP-sensitive K(+) channels in pancreatic beta-cells through a phosphatidylinositol 3-kinase-dependent pathway

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Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes

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A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

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Identifiers

10.1074/JBC.M411727200

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

ResearchGate publication ID

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