(Q40494497)

21 September 2017

Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity (English)

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21 September 2017

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2

Arthur I Cederbaum

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21 September 2017

Jingxiang Bai

1

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21 September 2017

1 July 2004

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Molecular and Cellular Biochemistry

21 September 2017

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21 September 2017

262

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21 September 2017

1-2

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21 September 2017

165-176

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https://scigraph.springernature.com/pub.10.1023/b:mcbi.0000038232.61760.9e

21 September 2017

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cites work

Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it.

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12 December 2020

Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse

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12 December 2020

Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells

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12 December 2020

Induction of the mitochondrial permeability transition as a mechanism of liver injury during cholestasis: a potential role for mitochondrial proteases

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12 December 2020

The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity

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12 December 2020

Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.

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12 December 2020

Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes

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12 December 2020

Acetaminophen hepatotoxicity

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12 December 2020

Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment

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12 December 2020

Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

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12 December 2020

Toxicity of paracetamol in human hepatocytes. Comparison of the protective effects of sulfhydryl compounds acting as glutathione precursors

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12 December 2020

Oxidative and reductive metabolism by cytochrome P450 2E1.

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12 December 2020

Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system

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12 December 2020

Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse

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12 December 2020

Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts.

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12 December 2020

Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes.

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12 December 2020

Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1.

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12 December 2020

Calcium-dependent DNA damage and adenosine 3',5'-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury.

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12 December 2020

Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.

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12 December 2020

Markedly enhanced cytochrome P450 2E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-ethanol-fed rats

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12 December 2020

Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins.

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12 December 2020

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

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12 December 2020

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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12 December 2020

Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53.

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12 December 2020

CYP2E1-dependent toxicity and oxidative stress in HepG2 cells

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12 December 2020

N-acetylcysteine for paracetamol overdose

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12 December 2020

The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity

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12 December 2020

Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice

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12 December 2020

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

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12 December 2020

Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity

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12 December 2020

Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches

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12 December 2020

Mechanism of action and value of N-acetylcysteine in the treatment of early and late acetaminophen poisoning: a critical review

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12 December 2020

Ferrous ion supported in vivo lipid peroxidation induced by paracetamol--its relation to hepatotoxicity.

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12 December 2020

Protection of ethanol-mediated acetaminophen hepatotoxicity by triacetyloleandomycin, a specific inhibitor of CYP3A

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12 December 2020

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

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12 December 2020

Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway

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12 December 2020

Dissociation of covalent binding from the oxidative effects of acetaminophen. Studies using dimethylated acetaminophen derivatives

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12 December 2020

The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study

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12 December 2020

Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity

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12 December 2020

Fish oil, alcohol, and liver pathology: role of cytochrome P450 2E1

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12 December 2020

Genotoxicity of paracetamol in mice and rats

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12 December 2020

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

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12 December 2020

Paracetamol Overdosage Pharmacological Considerations and Clinical Management

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12 December 2020

Toxicity of paracetamol in cultured chick hepatocytes treated with methotrexate

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12 December 2020

Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion

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12 December 2020

Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides

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12 December 2020

Effects of ethanol and inhibitors on the binding and metabolism of acetaminophen and N-acetyl-p-benzoquinone imine by hepatic microsomes from control and ethanol-treated rats

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12 December 2020

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

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12 December 2020

Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy

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12 December 2020

Drug-induced lipid peroxidation in mice—I Modulation by monooxegenase activity, glutathione and selenium status

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12 December 2020

Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity

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12 December 2020

Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes.

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12 December 2020

Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice

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12 December 2020

Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen

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12 December 2020

Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen

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12 December 2020

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

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12 December 2020

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

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12 December 2020

Recognizing acetaminophen hepatotoxicity in chronic alcoholics

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12 December 2020

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death

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12 December 2020

Cytochrome P-4502E1: its physiological and pathological role

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12 December 2020

Paracetamol inhibits cell cycling and induces apoptosis in HL-60 cells.

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12 December 2020

Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice

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12 December 2020

10.1023/B:MCBI.0000038232.61760.9E

Identifiers

DOI

1 reference

PubMed ID

15532721

Dimensions Publication ID

21 September 2017

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1 reference

PubMed ID

15532721