(Q40503541)

21 September 2017

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title

Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy (English)

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21 September 2017

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L W Jin

1

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PubMed ID

7711360

21 September 2017

T Saitoh

series ordinal

2

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21 September 2017

1 February 1995

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21 September 2017

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21 September 2017

6

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21 September 2017

136-149

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21 September 2017

2

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https://scigraph.springernature.com/pub.10.2165/00002512-199506020-00006

21 September 2017

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12 December 2020

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The Albert Lasker Medical Awards. Role of the cyclic AMP-dependent protein kinase in signal transduction

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The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.

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Phorbol ester-induced neuritic alterations in the rat neocortex. Structural and immunocytochemical studies

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Nerve growth factor and the basal forebrain cholinergic system: a link in the etiopathology of neurodegenerative dementias?

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12 December 2020

Epidermal growth factor receptor expression in demented and aged human brain.

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12 December 2020

Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats

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12 December 2020

Aberrant casein kinase II in Alzheimer's disease

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12 December 2020

The site of the earliest lesions of Alzheimer's disease.

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12 December 2020

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

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12 December 2020

Decreased levels of protein kinase C in Alzheimer brain

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12 December 2020

Age-dependent alterations of microtubule-associated enzyme activities from bovine brain (protein kinase, adenosine triphosphatase, guanosine triphosphatase)

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12 December 2020

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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12 December 2020

Neurochemical enzyme changes in Alzheimer's and Pick's disease

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12 December 2020

Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells

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12 December 2020

Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein

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12 December 2020

The protein kinase C family: heterogeneity and its implications

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12 December 2020

Ultrastructural aspects of ageing rat hippocampus and effects of L-acetyl-carnitine treatment

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12 December 2020

Neuron-specific protein F1/GAP-43 shows substrate specificity for the beta subtype of protein kinase C.

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12 December 2020

Altered protein tyrosine phosphorylation in Alzheimer's disease

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex

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12 December 2020

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes.

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12 December 2020

Tyrosine phosphorylation systems in Alzheimer's disease pathology

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12 December 2020

Quantitation of protein kinase C by immunoblot--expression in different cell lines and response to phorbol esters

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12 December 2020

The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain

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12 December 2020

Tacrine in Alzheimer's disease

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12 December 2020

Mechanisms of induction of ornithine decarboxylase activity in tracheal epithelial cells by asbestiform minerals.

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12 December 2020

Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons

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12 December 2020

Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex

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12 December 2020

Differential involvement of protein kinase C isozymes in Alzheimer's disease

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12 December 2020

Stathmin: a relay phosphoprotein for multiple signal transduction?

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12 December 2020

Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions

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12 December 2020

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

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12 December 2020

Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.

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12 December 2020

Protein kinase C alteration is an early biochemical marker in Alzheimer's disease

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12 December 2020

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

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12 December 2020

Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release

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12 December 2020

Isolation and characterization of delta-subspecies of protein kinase C from rat brain

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12 December 2020

Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer's disease.

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12 December 2020

Down-regulation of protein kinase C is due to an increased rate of degradation

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12 December 2020

The structure, expression, and properties of additional members of the protein kinase C family.

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12 December 2020

Biosynthesis of acetyl-L-carnityl choline.

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12 December 2020

Dopamine receptor sensitivity in brain and retina of rats during aging

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12 December 2020

Regulation of phorbol ester binding and protein kinase C activity in aged rat brain.

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12 December 2020

Modulation by palmitoyl-carnitine of calcium activated, phospholipid-dependent protein kinase activity and inhibition of melanoma cell growth.

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12 December 2020

Patterns of aberrant sprouting in Alzheimer's disease

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12 December 2020

Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate

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12 December 2020

Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat.

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12 December 2020

Cyclosporin A inhibits proteolytic cleavage and degradation of membrane-bound protein kinase C in hepatocytes after stimulation by phorbol ester

1 reference

12 December 2020

Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome

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12 December 2020

Molecular cloning and characterization of the rat NMDA receptor

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12 December 2020

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

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12 December 2020

Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain

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12 December 2020

Basic fibroblast growth factor in Alzheimer's disease

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12 December 2020

A neuronal antigen in the brains of Alzheimer patients

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12 December 2020

Reduced cAMP-dependent phosphorylation in striatum and nucleus accumbens of aged rats: evidence of an altered functioning of D1 dopaminoceptive neurons

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12 December 2020

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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12 December 2020

Effects of aging on signal transmission and transduction systems in the gerbil brain: morphological and autoradiographic study

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12 December 2020

Phosphoprotein phosphatase activities in Alzheimer disease brain

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12 December 2020

Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture

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12 December 2020

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

1 reference

12 December 2020

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1 reference

12 December 2020

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth.

1 reference

12 December 2020

Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer's disease.

1 reference

12 December 2020

The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

1 reference

12 December 2020

Reduced in vitro phosphorylation of synapsin I (site 1) in Alzheimer's disease postmortem tissues

1 reference

12 December 2020

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension

1 reference

12 December 2020

Phorbol ester binding sites in human brain: characterization, regional distribution, age-correlation, and alterations in Parkinson's disease

1 reference

12 December 2020

Tyrosine protein kinase activity in normal rat tissues: brain

1 reference

12 December 2020

Synapsin I: a review of its distribution and biological regulation

1 reference

12 December 2020

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease

1 reference

12 December 2020

Therapeutic potential of protein kinase C inhibitors

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12 December 2020

Autoradiographic imaging of [3H]phorbol 12,13-dibutyrate binding to protein kinase C in Alzheimer's disease

1 reference

12 December 2020

Cyclic AMP-dependent protein kinase activity and synaptosomal protein phosphorylation in the brains of aged rats

1 reference

12 December 2020

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse

1 reference

12 December 2020

Phosphatidylcholine breakdown and signal transduction

1 reference

12 December 2020

Receptor protein tyrosine kinases and phosphatases

1 reference

12 December 2020

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

1 reference

12 December 2020

Regional localization of the regulatory subunit (RII beta) of the type II cAMP-dependent protein kinase in human brain

1 reference

12 December 2020

Subcellular distribution of adenosine 3',5'-monophosphate-dependent protein kinase in rat brain.

1 reference

12 December 2020

Contrasting patterns of protein phosphorylation in human normal and Alzheimer brain: Focus on protein kinase C and protein F1GAP-43

1 reference

12 December 2020

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate

1 reference

12 December 2020

Molecular insights into Alzheimer's disease

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12 December 2020

Phenothiazines reduce ischemic damage to the central nervous system

1 reference

12 December 2020

Protein kinase C--a question of specificity

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Impaired gene transcription and nuclear protein kinase C activation in the brain and liver of aged rats

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12 December 2020

Casein kinase II is associated with neurofibrillary tangles but is not an intrinsic component of paired helical filaments

1 reference

12 December 2020

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1 reference

12 December 2020

Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues

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12 December 2020

Signalling by receptor tyrosine kinases

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12 December 2020

Nonreceptor tyrosine protein kinases.

1 reference

12 December 2020

H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells

1 reference

12 December 2020

Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death

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12 December 2020

Protein kinases and phosphorylation in neurologic disorders and cell death

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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12 December 2020

Advances in Alzheimer's disease

1 reference

12 December 2020

Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes

1 reference

12 December 2020

Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease

1 reference

12 December 2020

Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release

1 reference

12 December 2020

The survival of rat cerebral cortical neurons in the presence of trophic APP peptides.

1 reference

12 December 2020

Tacrine as a treatment for Alzheimer's dementia: editor's note. An interim report from the FDA. A response from Summers et al

1 reference

12 December 2020

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

1 reference

12 December 2020

Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain.

1 reference

12 December 2020

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor.

1 reference

12 December 2020

Protein tyrosine kinase activity and its endogenous substrates in rat brain: a subcellular and regional survey

1 reference

12 December 2020

Tyrosine phosphorylation in early embryonic growth cones.

1 reference

12 December 2020

Localization of a defect in hypothalamic dopaminergic neurons of the aged brain that results in impaired PKA-dependent activation of tyrosine hydroxylase

1 reference

12 December 2020

Inhibition of gap junctional blockage by palmitoyl carnitine and TMB-8 in a rat liver epithelial cell line

1 reference

12 December 2020

CARNITINE AND ITS ROLE IN FATTY ACID METABOLISM

1 reference

12 December 2020

Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin.

1 reference

12 December 2020

The trk proto-oncogene encodes a receptor for nerve growth factor

1 reference

12 December 2020

The involvement of protein kinase C in activation-induced cell death in T-cell hybridoma

1 reference

12 December 2020

Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors

1 reference

12 December 2020

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

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12 December 2020

Tissue and cellular distribution of the extended family of protein kinase C isoenzymes

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12 December 2020

Mutagenesis of the regulatory domain of rat protein kinase C-eta. A molecular basis for restricted histone kinase activity.

1 reference

12 December 2020

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis

1 reference

12 December 2020

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1 reference

12 December 2020

Cerebral hypoxia: some new approaches and unanswered questions

1 reference

12 December 2020

Inhibition of epidermal growth factor binding in rat pancreatic acini by palmitoyl carnitine: evidence for Ca2+ and protein kinase C independent regulation.

1 reference

12 December 2020

Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study.

1 reference

12 December 2020

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF.

1 reference

12 December 2020

Increased in vitro phosphorylation of a Mr 60,000 protein in brain from patients with Alzheimer disease

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

12 December 2020

The role of protein kinase C in transmembrane signalling

1 reference

12 December 2020

BDNF and trkB mRNA expression in the hippocampal formation of aging rats

1 reference

12 December 2020

Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains.

1 reference

12 December 2020

10.2165/00002512-199506020-00006

Identifiers

DOI

1 reference

PubMed ID

7711360

Dimensions Publication ID

21 September 2017

0 references

1 reference

PubMed ID

7711360