(Q40504937)

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Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes (English)

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Europe PubMed Central

PubMed publication ID

21 September 2017

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apoptotic process

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mantle cell lymphoma

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Francesc Bosch

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Dolors Colomer

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object named as

Elias Campo

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object named as

Blanca Espinet

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Emili Montserrat

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object named as

Emili Montserrat

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Europe PubMed Central

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21 September 2017

author name string

Ana Ferrer

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21 September 2017

Silvia Marcé

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Europe PubMed Central

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21 September 2017

Beatriz Bellosillo

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Europe PubMed Central

PubMed publication ID

21 September 2017

Neus Villamor

4

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21 September 2017

Armando López-Guillermo

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21 September 2017

Francesc Solé

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21 September 2017

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1 November 2004

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21 September 2017

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21 September 2017

23

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21 September 2017

55

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21 September 2017

8941-8949

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Europe PubMed Central

PubMed publication ID

21 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1208084

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Molecular basis of mantle cell lymphoma

1 reference

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Inhibition of the proteasome induces cell cycle arrest and apoptosis in mantle cell lymphoma cells

1 reference

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Fludarabine, cyclophosphamide and mitoxantrone in the treatment of resistant or relapsed chronic lymphocytic leukaemia

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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The Bcl2 family: regulators of the cellular life-or-death switch

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Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

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Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis

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Staurosporine-induced death of MCF-7 human breast cancer cells: a distinction between caspase-3-dependent steps of apoptosis and the critical lethal lesions

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Natural resistance of acute myeloid leukemia cell lines to mitoxantrone is associated with lack of apoptosis

1 reference

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7 January 2021

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

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Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells

1 reference

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Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species

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Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia

1 reference

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7 January 2021

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Mantle cell lymphoma: presenting features, response to therapy, and prognostic factors.

1 reference

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7 January 2021

based on heuristic

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ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances

1 reference

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Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: Mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma

1 reference

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7 January 2021

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The Bcl-2 family: roles in cell survival and oncogenesis.

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7 January 2021

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The role of topoisomerase II in drug resistance

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Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites

1 reference

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Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray

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Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression

1 reference

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Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma.

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Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia

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7 January 2021

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INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene

1 reference

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7 January 2021

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Mechanisms of resistance to topoisomerase I-targeting drugs

1 reference

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7 January 2021

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Mechanisms of resistance to nucleoside analogue chemotherapy in mantle cell lymphoma: a molecular case study

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The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma

1 reference

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Topoisomerase IIalpha expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome

1 reference

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7 January 2021

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Serial killers: ordering caspase activation events in apoptosis

1 reference

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Phase II trial of fludarabine monophosphate as first-line treatment in patients with advanced follicular lymphoma: a multicenter study by the Groupe d'Etude des Lymphomes de l'Adulte

1 reference

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Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

1 reference

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Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia

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Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma

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Identifiers

10.1038/SJ.ONC.1208084

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

ResearchGate publication ID

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