(Q30882791)

27 June 2017

1 reference

title

Mechanisms of resistance to topoisomerase I-targeting drugs (English)

1 reference

antineoplastic resistance

27 June 2017

main subject

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576839

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206935

24 March 2024

author name string

Zeshaan A. Rasheed

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576839

24 March 2024

Eric H. Rubin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14576839

24 March 2024

language of work or name

English

0 references

publication date

1 October 2003

1 reference

27 June 2017

20 October 2003

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14576839

full work available at URL

24 March 2024

https://www.nature.com/articles/1206935.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206935

https://www.nature.com/articles/1206935

24 March 2024

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206935

24 March 2024

1 reference

27 June 2017

volume

22

1 reference

27 June 2017

issue

47

1 reference

27 June 2017

page(s)

7296-7304

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The Camptothecin-Resistant Topoisomerase I Mutant F361S Is Cross-Resistant to Antitumor Rebeccamycin Derivatives. A Model for Topoisomerase I Inhibition by Indolocarbazoles†

27 June 2017

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Mechanism of action of and resistance to quinolones

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Identification of a nucleolin binding site in human topoisomerase I

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Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus

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7 January 2021

S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

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Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin

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Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

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7 January 2021

Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin

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7 January 2021

DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenografts

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Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin

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7 January 2021

Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

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7 January 2021

Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.

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A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin

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7 January 2021

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

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7 January 2021

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

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7 January 2021

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

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7 January 2021

Reduced cellular accumulation of topotecan: a novel mechanism of resistance in a human ovarian cancer cell line

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7 January 2021

SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

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7 January 2021

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

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7 January 2021

Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe

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7 January 2021

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

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7 January 2021

Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair

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7 January 2021

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

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7 January 2021

Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin

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7 January 2021

The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies

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7 January 2021

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

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7 January 2021

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.

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7 January 2021

Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.

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7 January 2021

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer.

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7 January 2021

Mechanisms of resistance to camptothecins.

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7 January 2021

Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

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7 January 2021

Enhanced sensitivity to camptothecin in ataxia-telangiectasia cells and its relationship with the expression of DNA topoisomerase I.

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7 January 2021

Structure-activity relationship in O-glucuronidation of indolocarbazole analogs

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7 January 2021

Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer

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7 January 2021

Point mutations in the topoisomerase I gene in patients with non-small cell lung cancer treated with irinotecan

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7 January 2021

Cell density-dependent VP-16 sensitivity of leukaemic cells is accompanied by the translocation of topoisomerase IIalpha from the nucleus to the cytoplasm

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7 January 2021

The topoisomerase-related function gene TRF4 affects cellular sensitivity to the antitumor agent camptothecin

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7 January 2021

The topoisomerase I poison camptothecin generates a Chk1-dependent DNA damage checkpoint signal in fission yeast

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7 January 2021

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

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7 January 2021

Differential regulation of P53, c-Myc, Bcl-2, Bax and AFP protein expression, and caspase activity during 10-hydroxycamptothecin-induced apoptosis in Hep G2 cells

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7 January 2021

A simple method for the specific detection of Ren-1 renin

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DNA topoisomerases: structure, function, and mechanism

24 March 2024

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Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation

24 March 2024

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Transcription-dependent degradation of topoisomerase I-DNA covalent complexes

24 March 2024

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24 March 2024

DNA topoisomerases

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Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

24 March 2024

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Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

24 March 2024

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Expression of multidrug resistance-related transporters in human breast carcinoma

24 March 2024

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Human Genome and Diseases: A new series of reviews in CMLS Werner Syndrome: genetic and molecular basis of a premature aging disorder

24 March 2024

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DNA topoisomerase poisons as antitumor drugs

24 March 2024

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SUMO, ubiquitin's mysterious cousin

24 March 2024

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Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase path

24 March 2024

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No alteration in DNA topoisomerase I gene related to CPT-11 resistance in human lung cancer.

24 March 2024

68

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Co-amplification of dhfr and a homologue of hmsh3 in a Chinese hamster methotrexate-resistant cell line correlates with resistance to a range of chemotherapeutic drugs

24 March 2024

69

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206935

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

24 March 2024

89

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206935

The role of glucuronidation in 7-ethyl-10-hydroxycamptothecin resistance in vitro

24 March 2024

94

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Gene mutation analysis and quantitation of DNA topoisomerase I in previously untreated non-small cell lung carcinomas.

24 March 2024

95

1 reference

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Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

24 March 2024

97

1 reference

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24 March 2024

DNA topoisomerases

111

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206935

BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells.

24 March 2024

116

1 reference

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p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line

24 March 2024

119

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24 March 2024

Identifiers

1 reference

Dimensions Publication ID

27 June 2017

1005332382

0 references

1 reference