(Q40538990)

21 September 2017

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. (English)

1 reference

21 September 2017

Patrick Concannon

2

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author name string

Karen Cerosaletti

series ordinal

1

1 reference

PubMed ID

15234984

21 September 2017

language of work or name

English

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publication date

1 July 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

38813-38819

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21 September 2017

37

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

The Mre11 complex and ATM: collaborating to navigate S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Ataxia-telangiectasia: diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Chk2 activation dependence on Nbs1 after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Interaction of FANCD2 and NBS1 in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404294200

21 January 2018

Identifiers

DOI

10.1074/JBC.M404294200

1 reference

21 September 2017

1 reference

PubMed ID

15234984