(Q40556741)

English

Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.

scientific article published on May 2004

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15140185%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15140185%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15140185%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Nianhang Chen

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15140185%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Maarten E A Reith

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15140185%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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1 May 2004

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28 December 2019

Journal of Neurochemistry

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28 December 2019

89

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28 December 2019

4

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28 December 2019

853-864

1 reference

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28 December 2019

A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Permeation and gating residues in serotonin transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluorophenyl)tropane

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

The two-state model of receptor activation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

An intermediate state of the gamma-aminobutyric acid transporter GAT1 revealed by simultaneous voltage clamp and fluorescence

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Modeling of the interaction of Na+ and K+ with the binding of dopamine and [3H]WIN 35,428 to the human dopamine transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Delineation of an endogenous zinc-binding site in the human dopamine transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Critical amino acid residues in transmembrane span 7 of the serotonin transporter identified by random mutagenesis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

[3H]WIN 35,428 binding to the dopamine uptake carrier. II. Effect of membrane fractionation procedure and freezing

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Plasma membrane monoamine transporters: structure, regulation and function

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Dopamine transporter ligand binding domains. Structural and functional properties revealed by limited proteolysis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Neurobiology of addiction

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02386.X

21 January 2018

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