(Q40568235)

21 September 2017

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title

Tumor suppressor genes in molecular medicine (English)

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21 September 2017

F Hoppe-Seyler

1

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author name string

K Butz

series ordinal

2

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21 September 2017

publication date

1 August 1994

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Journal of Molecular Medicine

21 September 2017

published in

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21 September 2017

volume

72

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21 September 2017

issue

8

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21 September 2017

page(s)

619-630

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Changes in growth and tumorigenicity following reconstitution of retinoblastoma gene function in various human cancer cell types by microcell transfer of chromosome 13

21 September 2017

cites work

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12 December 2020

Second tumors after treatment of childhood malignancies

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12 December 2020

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12 December 2020

Amplification of a gene encoding a p53-associated protein in human sarcomas

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12 December 2020

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

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12 December 2020

Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a marker for disease progression

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12 December 2020

Protein Domains Governing Interactions Between E2F, the Retinoblastoma Gene Product, and Human Papillomavirus type 16 E7 Protein

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12 December 2020

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

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12 December 2020

Transcriptional regulation by the retinoblastoma protein

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12 December 2020

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

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12 December 2020

Biochemical properties of the growth suppressor/oncoprotein p53

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12 December 2020

Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes

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12 December 2020

Follow-up of retinoblastoma patients having prenatal and perinatal predictions for mutant gene carrier status using intragenic polymorphic probes from the RB1 gene

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12 December 2020

Identification of a chromosome 18q gene that is altered in colorectal cancers

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12 December 2020

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12 December 2020

The p53 tumour suppressor gene

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12 December 2020

Association of the APC tumor suppressor protein with catenins

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12 December 2020

p53 mutations increase resistance to ionizing radiation

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12 December 2020

Somatic mutations in the neurofibromatosis 1 gene in human tumors

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12 December 2020

APC mutations occur early during colorectal tumorigenesis

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12 December 2020

Introduction of a normal human chromosome 11 into a Wilms' tumor cell line controls its tumorigenic expression

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12 December 2020

Antioncogenes and human cancer

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12 December 2020

Human tumor suppressor genes

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12 December 2020

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

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12 December 2020

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

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12 December 2020

The retinoblastoma protein and cell cycle regulation

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12 December 2020

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

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12 December 2020

Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate

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12 December 2020

Malignancy of Somatic Cell Hybrids

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12 December 2020

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer

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12 December 2020

Tumor suppressor genes

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12 December 2020

Genetics and cytogenetics of retinoblastoma

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12 December 2020

p53 expression and prognosis in gastric carcinoma

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12 December 2020

Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations

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12 December 2020

Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas

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12 December 2020

Activation of the cryptic DNA binding function of mutant forms of p53.

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12 December 2020

Clinical implications of the p53 tumor-suppressor gene

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12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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12 December 2020

The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the α-fetoprotein status

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12 December 2020

Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation

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12 December 2020

Accumulation of p53 protein correlates with a poor prognosis in human lung cancer

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12 December 2020

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

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12 December 2020

Cancer. p53, guardian of the genome

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12 December 2020

Identification and characterization of the familial adenomatous polyposis coli gene

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12 December 2020

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

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12 December 2020

Clinical features and natural history of von Hippel-Lindau disease

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12 December 2020

Physical interaction of the retinoblastoma protein with human D cyclins

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12 December 2020

Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22

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12 December 2020

The role of E2F in the mammalian cell cycle

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12 December 2020

WAF1, a potential mediator of p53 tumor suppression

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12 December 2020

The retinoblastoma protein as a transcriptional repressor

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12 December 2020

Lack of linkage of familial Wilms' tumour to chromosomal band 11 p13

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12 December 2020

High levels of p53 protein in UV-irradiated normal human skin

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12 December 2020

The genetics of Wilms' tumor

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12 December 2020

The p53 tumor-suppressor gene

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12 December 2020

Wild-type p53 can down-modulate the activity of various promoters

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12 December 2020

The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot

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12 December 2020

Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease

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12 December 2020

Frequent somatic mutations of the APC gene in human pancreatic cancer

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12 December 2020

Loss of expression of the DCC gene during progression of colorectal carcinomas in familial adenomatous polyposis and non-familial adenomatous polyposis patients

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12 December 2020

Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?

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12 December 2020

Follow-up study of twenty-four families with Li-Fraumeni syndrome

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12 December 2020

In search of the functions of normal p53 protein

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12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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12 December 2020

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

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12 December 2020

Rate-limiting steps: The genetics of pediatric cancers

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

Alleles of the APC gene: an attenuated form of familial polyposis

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12 December 2020

A structure-function analysis of transcriptional repression mediated by the WT1, Wilms' tumor suppressor protein

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12 December 2020

Molecular diagnosis of familial adenomatous polyposis.

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12 December 2020

p53 mutations in human cancers

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12 December 2020

Association of the APC gene product with beta-catenin

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12 December 2020

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

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12 December 2020

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

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12 December 2020

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

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12 December 2020

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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12 December 2020

The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein

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12 December 2020

p53 as a growth suppressor gene in HBV-related hepatocellular carcinoma cells.

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12 December 2020

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

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12 December 2020

Oncogenes and tumor suppressor genes in human lung carcinogenesis

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12 December 2020

The chromosomal basis of human neoplasia.

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12 December 2020

No room at the p53 inn

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12 December 2020

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

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12 December 2020

Mortality from second tumors among long-term survivors of retinoblastoma

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12 December 2020

Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas

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12 December 2020

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

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12 December 2020

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types

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12 December 2020

Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis

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12 December 2020

The adenomatous polyp and the hereditary polyposis syndromes

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12 December 2020

The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells

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12 December 2020

Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling

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12 December 2020

Retinoblastoma and the progression of tumor genetics

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12 December 2020

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells

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12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

Interactions of human papillomavirus transforming proteins with the products of tumor suppressor genes.

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12 December 2020

Screening patients for heterozygous p53 mutations using a functional assay in yeast

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12 December 2020

Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11.

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12 December 2020

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

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12 December 2020

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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12 December 2020

p21 is a universal inhibitor of cyclin kinases

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12 December 2020

Small Subgroup of Aggressive, Highly Proliferative Prostatic Carcinomas Defined by p53 Accumulation

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12 December 2020

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

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12 December 2020

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.

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12 December 2020

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

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12 December 2020

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage

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12 December 2020

Familial adenomatous polyposis: mutation at codon 1309 and early onset of colon cancer.

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12 December 2020

Genetic steps in colorectal cancer.

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12 December 2020

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

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12 December 2020

Analysis of the anti-p53 antibody response in cancer patients.

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12 December 2020

Participation of p53 protein in the cellular response to DNA damage

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12 December 2020

Molecular biology and gastric carcinoma

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12 December 2020

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers

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12 December 2020

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation

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12 December 2020

p53 function and dysfunction

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12 December 2020

Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein

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12 December 2020

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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12 December 2020

Interactions between p21ras proteins and their GTPase activating proteins

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12 December 2020

The tumor suppressor genes

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12 December 2020

p53: at the crossroads of molecular carcinogenesis and risk assessment

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12 December 2020

Deletions of 17p and p53 mutations in preneoplastic lesions of the lung

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12 December 2020

Genetics of cancer predisposition and progression

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12 December 2020

Cancer, catenins, and cuticle pattern: a complex connection.

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12 December 2020

Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

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12 December 2020

The neurofibromatosis type 1 gene encodes a protein related to GAP

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12 December 2020

Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival

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12 December 2020

The tumor suppressor p53.

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12 December 2020

Tumor suppressor genes studied by cell hybridization and chromosome transfer.

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12 December 2020

Genetic alterations underlying colorectal tumorigenesis

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12 December 2020

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

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12 December 2020

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

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12 December 2020

Intraocular tumor suppression of retinoblastoma gene-reconstituted retinoblastoma cells.

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12 December 2020

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma

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12 December 2020

Suppression of human colorectal carcinoma cell growth by wild-type p53

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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12 December 2020

Identification of FAP locus genes from chromosome 5q21

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12 December 2020

Physical and functional interaction between WT1 and p53 proteins

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12 December 2020

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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12 December 2020

The multistep nature of cancer

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12 December 2020

Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene

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12 December 2020

p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis

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12 December 2020

Molecular characterization of the retinoblastoma susceptibility gene

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12 December 2020

Antioncogenes and human cancer

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12 December 2020

NF1: a prevalent cause of tumorigenesis in human cancers?

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12 December 2020

Meeting highlights: National Cancer Institute workshop on Early Detection of Cancer--Challenges for Molecular Biology

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12 December 2020

Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

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12 December 2020

Tumor suppressor genes

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12 December 2020

The search for the familial breast/ovarian cancer gene

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12 December 2020

Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer

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12 December 2020

A mutant p53 tumor suppressor protein is a target for peptide-induced CD8+ cytotoxic T-cells

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12 December 2020

Identifiers

DOI

10.1007/BF00227456

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21 September 2017

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